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Receptor tyrosine kinase activity is known to occur in the absence of extracellular stimuli. Importantly, this “background” level of receptor phosphorylation is insufficient to effect a downstream response, suggesting that strict controls are present and prohibit full activation. Here a mechanism is described in which control of FGFR2 activation is provided by the adaptor protein Grb2. Dimeric Grb2...
The adaptor protein Grb2 is recruited to intracellular early signalling complexes of many receptor tyrosine kinases and plays an important role transducing signals leading to MAP kinase activation. To date the SH2 domain of Grb2 has been shown to mediate receptor interactions with phosphorylated tyrosine residues sited directly on the receptor or on auxiliary docking proteins. Here we report that...
In this study, the constrained minimum variance (CMV) control strategy was applied on the extrusion process. An in-line viscometer was designed and used to measure the viscosity of the polymer melt between the screw end and the die. Under constant temperature, the screw speed was treated as the plant control input, and the viscosity of the polymer melt was treated as the output. The system transfer...
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