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The pulmonary vasodilation induced by adrenomedullin may be beneficial in the acute pulmonary embolism (APE) setting. This study examined effects of adrenomedullin in sheep with microsphere-induced APE.Twenty four anesthetized, mechanically ventilated sheep were randomly assigned into 3 groups (n=8 per group): animals not subjected to any intervention (Sham), animals with APE induced by microspheres...
Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO 2 ). We compared the effects of pure oxygen (FiO 2 >90%) or room air (21% FiO 2 ) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Forty anesthetized, mechanically ventilated sheep (34.9±5.4kg), were randomly...
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