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It has been recently shown that cannabinoids may regulate the growth of many cell types. In the present work we examined the effect of the anandamide analogue (R)-methanandamide (MET) on androgen-dependent prostate LNCaP cell growth. We found that 0.1 μM MET had a mitogenic effect measured by [ 3 H]thymidine incorporation into DNA. The effect exerted by MET was blocked by the cannabinoid receptor...
Cannabinoids exert a variety of physiological and pharmacological responses in humans through interaction with specific cannabinoid receptors. Cannabinoid receptors described to date belong to the seven-transmembrane-domain receptor superfamily and are coupled through the inhibitory G i protein to adenylyl cyclase inhibition. However, downstream signal transduction mechanisms triggered by...
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