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Intestinal stem cells (ISCs) are regulated by the mesenchymal environment via physical interaction and diffusible factors. We examined the role of Indian hedgehog (Ihh) in mesenchymal organization and the mechanisms by which perturbations in epithelial−mesenchymal interactions affect ISC fate.We generated mice with intestinal epithelial-specific disruption of Ihh. Gross and microscopic anatomical...
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