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Transforming growth factor-β (TGFβ) has been shown to regulate steroid production and DNA synthesis in rat Leydig cells. We have investigated the effects of TGFβ on the secretion of extracellular matrix (ECM) proteins and on the cytoskeleton of immature rat Leydig cells in vitro. TGFβ caused significant morphological changes in Leydig cells, which were accompanied by significant increases in secretion...