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Pertussis is a highly contagious respiratory disease. Neither vaccination nor past infection provides long-term immunity.The analysis of the serological tests applicability for the diagnosis of pertussis in people from outbreaks.After a case of pertussis had been confirmed in school student in Wroclaw, we analyzed the incidence of cough in her contact group. The study involved 91 people: 75 students...
In Poland, similar to many highly immunized Western countries, a recent increase in cases of pertussis has been observed. This study aims to evaluate the level of potency fluctuations of the pertussis component of Polish-produced DTP vaccine due to the changes having occurred in production and potency testing procedures. We compared the potency of the pertussis component of DTP vaccine lots produced...
The present study indicates that the appearance of the B. pertussis harbouring prn2 gene allele variant (not found among clinical isolates before 1990s) may have been induced by long-term vaccination in Poland with DTP-composed vaccine strains presenting exclusively prn1. However, ptxS1A allele of pertussis toxin subunit S1 encoding gene, predominant in the currently isolated B. pertussis strains,...
Growing number of Bordetella pertussis infections in 1997–1998 in Poland overshadowed the successful national vaccination program. This situation prompted us to investigate if this shift reflects changes in the B. pertussis population. We investigated the possible divergence in genes encoding pertussis toxin subunit 1 (PtxS1) and pertactin (P.69) in B. pertussis population strains during the period...
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