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Synaptotagmin I or II (Syt I/II) is involved in Ca 2+ -regulated exocytosis of secretory vesicles, probably serving as a Ca 2+ -sensor via its C2A domain. Synaptotagmin is also known to be expressed in neuronal growth cone vesicles, but its functional involvement in neurite outgrowth remains largely unknown. In this study, we examined the function of Syt I/II in neurite...