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Liberation of Ca 2+ from the endoplasmic reticulum (ER) through inositol trisphosphate receptors (IP 3 R) is modulated by the ER Ca 2+ content, and overexpression of SERCA2b to accelerate Ca 2+ sequestration into the ER has been shown to potentiate the frequency and amplitude of IP 3 -evoked Ca 2+ waves in Xenopus oocytes. Here, we examined the effects...
The intracellular second messenger cyclic ADP-ribose (cADPR) induces Ca 2+ release through the activation of ryanodine receptors (RyRs). Moreover, it has been suggested that cADPR may serve an additional role to modulate sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) pump activity, but studies have been complicated by concurrent actions on RyR. Here, we explore the actions of cADPR...
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