Wyniki wyszukiwania dla: Bernard Weber

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Relationship of oxidative stress to visceral adiposity in youth and role played by vitamin D

Hanen Samouda, Carine De Beaufort, Georges Gilson, Anna Schritz, więcej

Background Visceral adipose tissue (VAT) accumulation is a major cardiometabolic risk factor, associated with increased inflammation. Oxidative stress (OS) is also associated with inflammation and cardiometabolic issues, yet mainly through general obesity. Both OS and obesity were linked to vitamin D deficiency. Objectives To investigate whether OS increase is associated with VAT accumulation in...

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Etiology of viral respiratory infections in Northern Lao People's Democratic Republic

Chantal J. Snoeck, Valy Ponghsavath, Nina Luetteke, Sabine Kaufmann, więcej

Journal of Medical Virology > 90 > 10 > 1553 - 1558

In Lao People's Democratic Republic (PDR), acute respiratory infections overburden the health care system, but viral etiology, genetic diversity, and seasonality, especially in light of the introduction of influenza vaccination in the country, are poorly understood. From August 2010 to April 2011, 309 outpatients were recruited at the Luang Prabang Provincial Hospital covering highland Lao communities...

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The distribution of hepatitis B virus genotypes in Thailand

Suda Louisirirotchanakul, Christophe M. Olinger, Panida Arunkaewchaemsri, Yong Poovorawan, więcej

Journal of Medical Virology > 84 > 10 > 1541 - 1547

Phylogenetic analysis was performed on hepatitis B virus (HBV) strains obtained from 86 hepatitis B surface antigen (HBsAg) positive donors from Thailand originating throughout the country. Based on the S gene, 87.5% of strains were of genotype C while 10.5% were of genotype B, with all genotype B strains obtained from patients originating from the central or the south Thailand. No genotype B strains...

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Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer

Sergio Maluta, Moshe Schaffer, Fabio Pioli, Stefano Dall’Oglio, więcej

Strahlentherapie und Onkologie > 2011 > 187 > 10 > 619-625

Purpose To evaluate the therapeutic effect of delivering regional hyperthermia (HT) plus chemoradiotherapy (CRT) in patients suffering from locally advanced unresectable pancreatic cancer (LAPC). Methods Between January 2000 and December 2008, 68 patients affected by primary (56/68) or recurrent (12/68) LAPC were treated either with CRT alone or CRT plus HT. Radiotherapy (RT) consisted of 3D conformal...

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European collaborative evaluation of the enzygnost HBsAg 6.0 assay: Performance on hepatitis B virus surface antigen variants

Ana Avellón, José M. Echevarría, Bernard Weber, Michael Weik, więcej

Journal of Medical Virology > 83 > 1 > 95 - 100

Amino acid changes within the major antigenic determinant of the hepatitis B virus (HBV) surface antigen (HBsAg) may modify eventually the antigenic properties of the protein and may have impact on the sensitivity of diagnostic assays. Modifications in the design of an assay can, however, improve significantly its ability to detect HBV mutants. One hundred forty‐seven clinical samples containing HBsAg...

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Simulation of the plantar skin, postural stabilization and cognition

Philippe Villeneuve, Sarah Recoules, Bernard Weber

Kinesitherapie, la revue > 2010 > 10 > 102 > 25

artykuł

Study of intra-subject random variations of stabilometric parameters

Pierre-Marie Gagey, Bernard Weber

Medical & Biological Engineering & Computing > 2010 > 48 > 8 > 833-835

This study of intra-subject random variations of stabilometric parameters was achieved in the context of the standardized clinical stabilometry, in use in France and Southern Europe since 1985. The outstanding interest of stabilometry to follow up patients makes the results of this study indispensable for clinicians and their international publication is particularly important as, these days, the...

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Hepatitis B virus genotype E surface antigen detection with different immunoassays and diagnostic impact of mutations in the preS/S gene

Christophe M. Olinger, Bernard Weber, Jesse A. Otegbayo, Wim Ammerlaan, więcej

Medical Microbiology and Immunology > 2007 > 196 > 4 > 247-252

The major neutralizing epitope, the “a” determinant of the hepatitis B virus (HBV) genotype E surface antigen (HBsAg) is most divergent from that of genotype A, which is used for preparing monoclonal antibodies used in commercially available HBV reagents. To evaluate the performance of the latest generation of HBsAg detection assays with respect to genotype E HBsAg. Three commercial assays were evaluated...

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Evaluation of a new automated assay for hepatitis B surface antigen (HBsAg) detection VIDAS HBsAg Ultra

Bernard Weber, Natacha Van der Taelem-Brulé, Annemarie Berger, François Simon, więcej

Journal of Virological Methods > 2006 > 135 > 1 > 109-117

In a multicenter study a new automated screening assay, VIDAS HBsAg Ultra (long (L) and short (S) incubation protocol (Biomérieux, Marcy l’Etoile, France), was compared to a well established test (AxSYM HBsAg v2, Abbott Diagnostics, Wiesbaden, Germany) for the detection of hepatitis B virus (HBV) surface antigen (HBsAg). A total of 32 seroconversion panels, sera from the chronic phase of infection,...

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Analyzing Wrongness as Sanction-Worthiness

Todd Bernard Weber

The Journal of Value Inquiry > 2006 > 40 > 1 > 23-31

artykuł

Genetic variability of the S gene of hepatitis B virus: clinical and diagnostic impact

Bernard Weber

Journal of Clinical Virology > 2005 > 32 > 2 > 102-112

The genetic variability of hepatitis B virus (HBV) represents a challenge for the sensitivity of immunologic and molecular based assays. Based on sequence divergence in the entire genome of >8%, HBV genomes have been classified into eight groups designated A to H. The genotypes of HBV have distinct geographical distributions. Although preliminary clinical studies seem to indicate that there is...

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Detection of an acute asymptomatic HBsAg negative hepatitis B virus infection in a blood donor by HBV DNA testing

Bernard Weber, Annelies Mühlbacher, Walter Melchior

Journal of Clinical Virology > 2005 > 32 > 1 > 67-70

The issue of HBV DNA screening on blood donations is controversially discussed since the economic impact of post-transfusion hepatitis B is expected to be relatively low. We report on a case of HBsAg negative unapparent acute HBV infection, which was detected by HBV NAT testing on 96-member maxi-pools with a commercially available NAT assay, which has a detection threshold of 3IU/mL of plasma. The...

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Fourth generation human immunodeficiency virus (HIV) screening assays with an improved sensitivity for p24 antigen close the second diagnostic window in primary HIV infection

Bernard Weber, Thomas Meier, Gisela Enders

Journal of Clinical Virology > 2002 > 25 > 3 > 357 - 359

artykuł

The Moral Dilemmas Debate, Deontic Logic, and the Impotence of Argument

Todd Bernard Weber

Argumentation > 2002 > 16 > 4 > 459-472

In this paper I argue for modesty concerning what theoretical reason can accomplish in the moral dilemmas debate. Specifically, I contend that philosophers' conclusions for or against moral dilemmas are driven less by rational argument and more by how the moral world intuitively appears to them. I support this thesis by first considering an argument against moral dilemmas, the argument from deontic...

artykuł

Human cytomegalovirus infection: diagnostic potential of recombinant antigens for cytomegalovirus antibody detection

Bernard Weber, Annemarie Berger, Holger Rabenau

Journal of Virological Methods > 2001 > 96 > 2 > 157 - 170

Recombinant antigen-based enzyme immunoassays (EIAs) for the detection of human cytomegalovirus (HCMV) specific antibody are believed to yield a higher sensitivity and specificity than virus lysate EIAs. The aim of the present study was to evaluate the accuracy of newly established HCMV assays (Copalis CMV Multiplex, Sorin; Cobas Core CMV IgG and IgM EIAs, Roche Diagnostics; Anti-HCMV recombinant...

artykuł

Tragic Dilemmas and the Priority of the Moral

Todd Bernard Weber

The Journal of Ethics > 2000 > 4 > 3 > 191-209

My purpose in this paper is to argue that we are not vulnerableto inescapable wrongdoing occasioned by tragic dilemmas. I directmy argument to those who are most inclined to accept tragicdilemmas: those of broadly Nietzschean inclination who reject``modern moral philosophy'' in favor of the ethical ideas of theclassical Greeks. Two important features of their project are todeny the usefulness of the...

artykuł

Screening of blood donors for human cytomegalovirus (HCMV) IgG antibody with an enzyme immunoassay using recombinant antigens

Bernard Weber, El Hadji M. Bargane Fall, Annemarie Berger, Hans Wilhelm Doerr

Journal of Clinical Virology > 1999 > 14 > 3 > 173 - 181

Background: Screening of blood donors for human cytomegalovirus (HCMV) infection is usually performed by the combined detection of specific IgG and IgM antibody. However, in most of the cases of primary infection HCMV IgG seroconversion is observed concomitantly to IgM production and HCMV IgM antibody detection for blood donor screening is subject to a relatively high frequency of false positive results...

artykuł

Multicenter evaluation of a new rapid automated human immunodeficiency virus antigen detection assay

Bernard Weber, Annelies Mühlbacher, Ulrike Michl, Giancarlo Paggi, więcej

Journal of Virological Methods > 1999 > 78 > 1-2 > 61 - 70

Although human immunodeficiency virus (HIV) antigen assays are of limited value for monitoring antiretroviral therapy, they play an important role for confirmatory testing of fourth generation HIV screening enzyme immunoassay (EIA) reactive samples. In a multicenter study, a new automated rapid p24 antigen assay, Elecsys(R) HIV Ag (Roche Diagnostics Boehringer Mannheim GmbH, Penzberg, Germany), was...

artykuł

Reduction of the diagnostic window with a new combined p24 antigen and human immunodeficiency virus antibody screening assay

Lutz Gürtler, Annelies Mühlbacher, Ulrike Michl, Hanns Hofmann, więcej

Journal of Virological Methods > 1998 > 75 > 1 > 27-38

In order to reduce the window phase between time of human immunodeficiency virus (HIV) infection and laboratory diagnosis, new fourth generation screening assays which permit a simultaneous detection of HIV antigen and antibody have been developed. In a multicenter study, a new automated fourth generation assay, Enzymun-Test(R) HIV Combi (Boehringer Mannheim GmbH) was compared to third generation...

artykuł

Detection of retroviral antibodies in primary biliary cirrhosis

Bernard Weber, Annemarie Berger, Hans Wilhelm Doerr

The Lancet > 1998 > 352 > 9122 > 149

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