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Lipid-laden macrophages are a prominent feature of rupture-prone regions of atherosclerotic plaques. These cells express Tissue factor (TF), which after plaque rupture may be exposed to the bloodstream, resulting in activation of the extrinsic coagulation pathway. Since TF is a major determinant of thrombin generation, we have investigated the possibility that macrophages or macrophage foam cells...
The effect of gemfibrozil treatment on very low (VLDL) and low (LDL) density lipoprotein subfractions has been investigated in 9 moderate hypertriglyceridemic (HTG) patients (triglyceride (TG) levels 237-426 mg/dl). Three VLDL subfractions, VLDL1 (Sf 175-400), VLDL2 (Sf 100-175) and VLDL3 (Sf 20-100) and 4 LDL subspecies, LDL1 (1.023-1.028 g/ml), LDL2 (1.029-1.037 g/ml), LDL3 (1.038-1.049 g/ml) and...
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