Search results for: Alain Serraf

Items from 1 to 20 out of 77 results

article

Transfusion‐related acute hepatic injury following postoperative platelets administration in pediatric patients undergoing the Fontan procedure

Uri Pollak, Tatyana Ruderman, Sharon Borik‐Chiger, David Mishaly, more

Congenital Heart Disease > 14 > 6 > 968 - 977

Objective The final common pathway of single ventricle patients is the Fontan procedure. Among the immediate postoperative complications is acute hepatic injury presented by marked elevation of liver enzymes (alanine transaminase [ALT] and aspartate transaminase [AST]). We aimed to determine the contribution of blood products transfusion to acute hepatic injury. Design Single center retrospective...

chapter

Truncus Arteriosus

Eduardo M. Cruz, Steven Goldberg, Victor O. Morell, Bertrand Léobon, more

Critical Care of Children with Heart Disease > Specific Cardiac Lesions > 383-398

Truncus Arteriosus (TA) is a rare congenital cardiac malformation, firstly described by Wilson in 1798 and reported with an incidence between 0.006 and 0.043 per 1,000 live births. It accounts for 0.7% of all congenital cardiac malformations [1] and for 1–2% of congenital heart diseases identified at autopsies. This disease occurs with equal frequency in male and female gender and it has no racial...

article

Central role of interferon-beta in thymic events leading to myasthenia gravis

Perrine Cufi, Nadine Dragin, Nathalie Ruhlmann, Julia Miriam Weiss, more

Journal of Autoimmunity > 2014 > 52 > Complete > 44-52

The thymus plays a primary role in early-onset Myasthenia Gravis (MG) mediated by anti-acetylcholine receptor (AChR) antibodies. As we recently showed an inflammatory and anti-viral signature in MG thymuses, we investigated in detail the contribution of interferon (IFN)-I and IFN-III subtypes in thymic changes associated with MG. We showed that IFN-I and IFN-III subtypes, but especially IFN-β, induced...

article

Hemodynamics and arteriovenous malformations in cavopulmonary anastomosis: The case for residual antegrade pulsatile flow

Roland Henaine, Mathieu Vergnat, Olaf Mercier, Alain Serraf, more

The Journal of Thoracic and Cardiovascular Surgery > 2013 > 146 > 6 > 1359-1365

Continuous flow in Fontan circulation results in impairment of pulmonary artery endothelial function, increased pulmonary vascular resistance, and, potentially, late failure of Fontan circulation. Bidirectional cavopulmonary shunt is the interim procedure in palliation of patients with single-ventricle physiology, but pulmonary arteriovenous malformations occur in many patients. In a porcine chronic...

article

Effects of lack of pulsatility on pulmonary endothelial function in the Fontan circulation

Roland Henaine, Mathieu Vergnat, Emile A. Bacha, Bruno Baudet, more

The Journal of Thoracic and Cardiovascular Surgery > 2013 > 146 > 3 > 522-529

Continuous flow in the Fontan circulation results in impairment of pulmonary artery endothelial function, increased pulmonary arterial resistance, and, potentially, late failure of Fontan circulation. We investigated the mechanisms of vascular remodeling and altered vascular reactivity associated with chronic privation of pulsatility on pulmonary vasculature.A total of 30 pigs were evenly distributed...

article

276: Potts’ shunt in children with idiopathic pulmonary arterial hypertension: long-term results

Alban-Elouen Baruteau, Alain Serraf, Maryline Lévy, Jérôme Petit, more

Archives of Cardiovascular Diseases Supplements > 2013 > 5 > 1 > 93

Idiopathic pulmonary arterial hypertension (IPAH) remains a progressive fatal disease. Palliative Potts'shunt has been proposed in children displaying supra-systemic IPAH.A retrospective multicenter study to evaluate Potts'shunt in pediatric IPAH.Between 2003 and 2010, 8 children with supra-systemic IPAH and in WHO functional class IV despite medical PAH therapy underwent Potts'shunt. Age at IPAH...

article

ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)

Helmut Baumgartner, Philipp Bonhoeffer, Natasja M.S. de Groo, Fokko de Haan, more

Revista Portuguesa de Cardiologia (English Edition) > 2012 > 31 > 7-8 > 541

article

Electrical velocimetry as a tool for measuring cardiac output in small infants after heart surgery

Oswin Grollmuss, Serge Demontoux, André Capderou, Alain Serraf, more

Intensive Care Medicine > 2012 > 38 > 6 > 1032-1039

Purpose Cardiac output (CO), the product of stroke volume (SV) and heart rate, is essential to guarantee organ perfusion, especially in the intensive care setting. As invasive measurement of CO bears the risk of complications there is a need for non-invasive alternatives. We investigated if electrical velocimetry (EV) and transthoracic Doppler (Doppler-TTE) are interchangeable for the non-invasive...

article

Surgical palliation of primary pulmonary arterial hypertension by a unidirectional valved Potts anastomosis in an animal model

Minh Thanh Bui, Oswin Grollmus, Mohamedou Ly, Anca Mandache, more

The Journal of Thoracic and Cardiovascular Surgery > 2011 > 142 > 5 > 1223-1228

Patients with idiopathic pulmonary hypertension are at risk for right-sided heart failure and sudden death. Despite improvement in pharmacologic management, some still require lung transplantation. Potts anastomosis has been demonstrated as a good palliation in children to alleviate symptoms and medical therapy despite desaturation in the lower part of the body. Young adult patients with pulmonary...

article

Continuous Cerebral Perfusion for Aortic Arch Repair: Hypothermia Versus Normothermia

Mohamed Ly, François Roubertie, Emre Belli, Oswin Grollmuss, more

The Annals of Thoracic Surgery > 2011 > 92 > 3 > 942-948

Deep hypothermia with circulatory arrest (CA) is routinely used for aortic arch repair. Antegrade selective cerebral perfusion (ASCP) has been proposed to avoid neurologic complications. The optimal temperature during aortic arch repair with ASCP is not well established. We therefore compared early outcomes of patients undergoing aortic arch repair associated with intracardiac repair with ASCP either...

article

298 Percutaneous closure of atrial septal defects in children: what are the predictive factors of success?

Elise Barre, Jerome Petit, Jean Losay, Andre Capderou, more

Archives of Cardiovascular Diseases Supplements > 2011 > 3 > 1 > 99

Percutaneous atrial septal defect (ASD) closure is now a safe and efficient alternative to surgery in adults. In paediatric population, its feasibility is still uncertain and limited in young children with large defect. Our aim was to determine predictive factors of success of percutaneous ASD closure in this population.All patients less than 12 years-old who underwent an attempt of a percutaneous...

article

299 Palliative Potts anastomosis for primary pulmonary hypertension in children: mid-term results

Jérôme Petit, Alban Baruteau, Emre Belli, Alain Serraf

Archives of Cardiovascular Diseases Supplements > 2011 > 3 > 1 > 99

Despite permanent progress in medical treatments, primary pulmonary hypertension in children (PPHTC) remains a not curable disease with a severe prognosis. Moreover, continuous intravenous treatment is particularly unacceptable for the quality of survival at this age.Eisenmenger syndrome with large patent ductus arteriosus carries a relatively good prognosis with long-term survival. This prompted...

article

312 Exercise testing coupled with Doppler echocardiography: a simple, safe and effective method to assess the severity of coarctation of the aorta

Herve Ngayap Nemkam, Lucile Houyel, Anne-Sophie Leborgne-Meyer, Bertrand Stos, more

Archives of Cardiovascular Diseases Supplements > 2011 > 3 > 1 > 103

Peak systolic Doppler velocity at the aortic isthmus alone is not a good predictor of severity in patients with native or residual coarctation (CoA). A major argument in favour of a hemodynamically significant CoA is the presence of a diastolic gradient (DG) with characteristic “sawtooth” appearance of the Doppler pattern.to evaluate, in patients with some degree of aortic isthmus narrowing but without...

article

Editorial Comment

Alain Serraf

European Journal of Cardio-Thoracic Surgery > 2010 > 38 > 6 > 713

article

Surgical management of congenital heart defects associated with heterotaxy syndrome

Alain Serraf, Nawel Bensari, Lucile Houyel, André Capderou, more

European Journal of Cardio-Thoracic Surgery > 2010 > 38 > 6 > 721-727

Objective: Heterotaxy syndrome (HS) is generally associated with complex congenital cardiac defects and has a high morbidity and mortality despite recent surgical progress. Only few reports deal with an overall surgical population. Methods: Between 1989 and 2008, 139 patients with HS entered a programme of surgical repair. Fifty-one patients were suitable for univentricular heart repair (UVR) and...

article

Very early correction of anomalous left coronary artery from the pulmonary artery improves intensive care management

Laurent Bonnemains, Virginie Lambert, Anne Moulin-Zinch, Dany Youssef, more

Archives of Cardiovascular Diseases > 2010 > 103 > 11-12 > 579-584

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) can sometimes be diagnosed very early in newborns and thus be corrected surgically before any myocardial ischaemia occurs.To evaluate the influence of this very early surgery on intensive care management and long-term outcome.All children operated on for ALCAPA before the age of 1 year between 1995 and 2010 were considered...

article

Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery Associated With Severe Left Ventricular Dysfunction: Results in Normothermia

Emre Belli, Régine Roussin, Mohammed Ly, François Roubertie, more

The Annals of Thoracic Surgery > 2010 > 90 > 3 > 856-860

Repair of anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) carries a high risk of operation, particularly in those with poor left ventricular function. In this study, we assessed the outcomes of patients who presented with severe preoperative left ventricular dysfunction (shortening fraction <15%) who underwent the repair under normothermic bypass.Since September...

article

Right ventricular failure secondary to chronic overload in congenital heart disease: An experimental model for therapeutic innovation

Virginie Lambert, André Capderou, Emmanuel Le Bret, Catherine Rücker-Martin, more

The Journal of Thoracic and Cardiovascular Surgery > 2010 > 139 > 5 > 1197-1204.e1

Mortality and morbidity related to right ventricular failure remain a problem for the long-term outcome of congenital heart diseases. Therapeutic innovation requires establishing an animal model reproducing right ventricular dysfunction secondary to chronic pressure-volume overload.Right ventricular tract enlargement by transvalvular patch and pulmonary artery banding were created in 2-month-old piglets...

article

Outcome of coronary artery bypass grafting performed in young children

Antoine Legendre, Alain Chantepie, Emre Belli, Pascal R. Vouhé, more

The Journal of Thoracic and Cardiovascular Surgery > 2010 > 139 > 2 > 349-353

The long-term patency rate of coronary artery bypass grafting for which arterial grafts are used is known to be high in the pediatric population. However, this issue remains uncertain in children under 3 years of age. Here, we report the outcome in this specific population.From July 1988 to July 2007, 18 children less than 3 years of age (age at operation, 0.1–35 months; median, 4 months) underwent...

article

309 Decreased myocardial capillary density in failing functionally univentricular heart (FUVH): a morphometric study

Ngoc-Tram To, Catherine Rucker-Martin, Lucile Houyel, Vincent De Montpreville, more

Archives of Cardiovascular Diseases Supplements > 2010 > 2 > 1 > 101

End-stage ventricular dysfunction is the most common cause of mortality in adults with FUVH. The physiopathology of this condition remains unclear.End-stage dilated as well as hypertrophic cardiomyopathies experience reduced capillary density. In FUVH physiology, volume overload leads to ventricular dilatation, followed by myocardial hypertrophy. We therefore hypothesize that FUVH also demonstrate...

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Search results for: Alain Serraf

Transfusion‐related acute hepatic injury following postoperative platelets administration in pediatric patients undergoing the Fontan procedure

Truncus Arteriosus

Central role of interferon-beta in thymic events leading to myasthenia gravis

Hemodynamics and arteriovenous malformations in cavopulmonary anastomosis: The case for residual antegrade pulsatile flow

Effects of lack of pulsatility on pulmonary endothelial function in the Fontan circulation

276: Potts’ shunt in children with idiopathic pulmonary arterial hypertension: long-term results

ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)

Electrical velocimetry as a tool for measuring cardiac output in small infants after heart surgery

Surgical palliation of primary pulmonary arterial hypertension by a unidirectional valved Potts anastomosis in an animal model

Continuous Cerebral Perfusion for Aortic Arch Repair: Hypothermia Versus Normothermia

298 Percutaneous closure of atrial septal defects in children: what are the predictive factors of success?

299 Palliative Potts anastomosis for primary pulmonary hypertension in children: mid-term results

312 Exercise testing coupled with Doppler echocardiography: a simple, safe and effective method to assess the severity of coarctation of the aorta

Editorial Comment

Surgical management of congenital heart defects associated with heterotaxy syndrome

Very early correction of anomalous left coronary artery from the pulmonary artery improves intensive care management

Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery Associated With Severe Left Ventricular Dysfunction: Results in Normothermia

Right ventricular failure secondary to chronic overload in congenital heart disease: An experimental model for therapeutic innovation

Outcome of coronary artery bypass grafting performed in young children

309 Decreased myocardial capillary density in failing functionally univentricular heart (FUVH): a morphometric study

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