Search results for: Yiyao Liu

Items from 1 to 20 out of 47 results

article

Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy

Peizheng Xiong, Xiaodan Wei, Li Zhou, Wanyi Zhou, more

Advanced Functional Materials > 34 > 44 > n/a - n/a

Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as an effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) and the reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO₂/GA) is developed to synergistically...

article

Rigid linker peptides improve the stability and anti‐inflammation effect of human serum albumin and α‐melanocyte‐stimulating hormone fusion proteins

Yiyao Liu, Yang Li, Xueyan Wei, Inam Ullah, more

Biotechnology Journal > 19 > 3 > n/a - n/a

The anti‐inflammatory effect of α‐melanocyte‐stimulating hormone (α‐MSH) in the central nervous system (CNS) has been reported for 40 years. However, the short half‐life of α‐MSH limits its clinical applications. The previous study has shown that a fusion protein comprising protein transduction domain (PTD), human serum albumin (HSA), and α‐MSH extends the half‐life of α‐MSH, but its anti‐inflammatory...

article

Biomimetic Nano‐Immunoactivator via Ionic Metabolic Modulation for Strengthened NIR‐II Photothermal Immunotherapy

Xiaodan Wei, Honglin Huang, Junhan Guo, Ningxi Li, more

Small > 19 > 49 > n/a - n/a

Reprogramming the immunologically “cold” environment of solid tumors is currently becoming the mainstream strategy to elicit powerful and systemic anticancer immunity. Here, a facile and biomimetic nano‐immunnoactivator (CuS/Z@M_4T1) is detailed by engineering a Zn²⁺‐bonded zeolitic imidazolate framework‐8 (ZIF‐8) with CuS nanodots (NDs) and cancer cell membrane for amplified near‐infrared‐II (NIR‐II)...

article

Characterization of the role of TMEM175 in an in vitro lysosomal H⁺ fluxes model

Chuanyan Yang, Fuyun Tian, Mei Hu, Chunlan Kang, more

The FEBS Journal > 290 > 19 > 4641 - 4659

Lysosome acidification is a dynamic equilibrium of H⁺ influx and efflux across the membrane, which is crucial for cell physiology. The vacuolar H⁺ ATPase (V‐ATPase) is responsible for the H⁺ influx or refilling of lysosomes. TMEM175 was identified as a novel H⁺ permeable channel on lysosomal membranes, and it plays a critical role in lysosome acidification. However, how TMEM175 participates in lysosomal...

article

CoNPR1 and CoNPR3.1 are involved in SA‐ and MeSA‐ mediated growth of the pollen tube in Camellia oleifera

Mengqi Lu, Junqin Zhou, Yiyao Liu, Jin Yang, more

Physiologia Plantarum > 172 > 4 > 2181 - 2190

Salicylic acid (SA) is a plant hormone involved in a series of growth, development, and stress responses in plants. Nonexpressor of pathogenesis‐related genes 1 (NPR1) is the core regulatory gene in the process of SA‐mediated systemic acquired resistance (SAR). Whether NPR1 is involved in pollen tube growth mediated by SA and its derivative MeSA (methyl salicylate) remains to be explored. Here, we...

article

Shear stress promotes anoikis resistance of cancer cells via caveolin‐1‐dependent extrinsic and intrinsic apoptotic pathways

Shun Li, Yu Chen, Yuehui Zhang, Xiaomin Jiang, more

Journal of Cellular Physiology > 234 > 4 > 3730 - 3743

Circulating tumor cells (CTCs) need to acquire resistance to anoikis to survive after they experience fluid shear stress in the circulatory and lymphatic systems. However, the mechanism by which tumor cells resist anoikis under shear stress conditions remains unknown. Here, we found that the application of low shear stress (LSS; 2 dyn/cm²) to human breast carcinoma cells (MDA‐MB‐231) resulted in increased...

article

New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure

Qiansheng Huang, Yiyao Liu, Yajie Chen, Chao Fang, more

Environmental Pollution > 2018 > 242 > PA > 914-921

Bisphenol A (BPA) exposure receives great ecotoxicological concern. However, gaps in knowledge, such as metabolism of BPA and inconsistent reports on reproductive toxicity, still exist. In this study, a marine fish model (Oryzias melastigma) was exposed to serial concentrations of BPA throughout its whole life cycle. The level of BPA-glucuronide (BPAG) dramatically increased throughout the embryonic...

article

Terahertz Electric Field-Induced Membrane Electroporation by Molecular Dynamics Simulations

Jingchao Tang, Hairong Yin, Jialu Ma, Wenfei Bo, more

The Journal of Membrane Biology > 2018 > 251 > 5-6 > 681-693

In this paper, the membrane electroporation induced by the terahertz electric field is simulated by means of the molecular dynamics method. The influences of the waveform and frequency of the applied terahertz electric field on the electroporation and the unique features of the process of the electroporation with the applied terahertz electric field are given. It shows that whether the electroporation...

article

Folate-targeted fluorescent nanomicelles co-loaded with elacridar and doxorubicin for overcoming multi-drug resistance and tumor imaging

Chengchen Zhang, Tingting Li, Jie Yan, Hong Yang, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2018 > 14 > 5 > 1847-1848

article

Co-delivery of doxorubicin and P-glycoprotein siRNA using pH-sensitive PLGA nanobubbles for synergistic tumor therapy

Jie Yan, Hong Yang, Xue Shen, Chengchen Zhang, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2018 > 14 > 5 > 1815

article

Co-delivery of photosensitizer and toll-like receptor ligands via pH triggered charge-reversal polyelectrolyte-functionalized graphene for enhanced cancer photoimmunotherapy

Yuan Tian, Xiaotian Guan, Lianhui Wang, Chunhui Wu, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2018 > 14 > 5 > 1871

article

Emerging roles of long non‐coding RNAs in the toxicology of environmental chemicals

Qiansheng Huang, Yiyao Liu, Sijun Dong

Journal of Applied Toxicology > 38 > 7 > 934 - 943

Environmental chemicals (ECs) are drawing great attention to their effects on health and their toxicological mechanisms are being investigated. Long non‐coding RNA (lncRNA) is a class of RNA with more than 200 nucleotides and does not have protein coding potential. Recently, it is emerging as a star molecule that participates in a wide range of physiological and pathological processes. It has been...

article

Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway

Jing Zhang, Li Li, Yueting Peng, Yu Chen, more

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2018 > 1865 > 1 > 172-185

Tumor cell can be significantly influenced by various chemical groups of the extracellular matrix proteins. However, the underlying molecular mechanisms involved in the interaction between cancer cells and functional groups in the extracellular matrix remain unknown. Using chemically modified surfaces with biological functional groups (CH₃, NH₂, OH), it was found that hydrophobic surfaces modified...

article

Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses

Qiansheng Huang, Yajie Chen, Lifeng Lin, Yiyao Liu, more

Science of The Total Environment > 2017 > 595 > C > 752-758

Bisphenol A (BPA) and its halogenated compounds (H-BPAs) are widely detected in the environmental media and organisms. However, their toxicological effects, especially chronic exposure at low doses, have not been fully compared. In this study, the effects of BPA and H-BPAs on the reproduction and development of Oryzias melastigma were systematically assessed and compared at various developmental stages...

article

Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy

Li Li, Ping Tang, Shun Li, Xiang Qin, more

Medical Oncology > 2017 > 34 > 10 > 1-10

Notch signaling pathway is evolutionarily conserved in mammals, which plays an important role in cell development and differentiation. In recent years, increasing evidence has shown that aberrant activation of Notch is associated with tumor process. Aberrant activation of Notch signaling pathway has been found in many different solid tumors can induce cell proliferation, metastasis and epithelial-mesenchymal...

article

Magnetic/fluorescent hybrid PLGA nanoparticles for doxorubicin/VEGF siRNA co-delivery and tumor imaging

Xue Shen, Jie Yan, Chengchen Zhang, Yue Geng, more

Journal of Controlled Release > 2017 > 259 > C > e160-e161

article

pH-triggered mesoporous silica nanocomplexes for imaging-guided drug delivery with enhanced cancer therapeutic efficiency

Tingting Li, Yue Geng, Zhongyuan Chen, Yi Feng, more

Journal of Controlled Release > 2017 > 259 > C > e174

article

Single wavelength light-mediated, synergistic bimodal cancer photoablation and amplified photothermal performance by graphene/gold nanostar/photosensitizer theranostics

Chunhui Wu, Dan Li, Lianhui Wang, Xiaotian Guan, more

Acta Biomaterialia > 2017 > 53 > C > 631-642

Light-triggered nanotheranostics opens a fascinating but challenging avenue to achieve simultaneous and highly efficient anticancer outcomes for multimodal therapeutic and diagnostic modalities. Herein, a multifunctional phototheranostics based on a photosensitizer-assembled graphene/gold nanostar hybrid (GO/AuNS-PEG) was developed for cancer synergistic photodynamic (PDT) and photothermal therapy...

article

Simultaneous pathway mapping and behavior understanding with crowdsourced sensing in WLAN environment

Mu Zhou, Qiao Zhang, Zengshan Tian, Yiyao Liu, more

Ad Hoc Networks > 2017 > 58 > C > 160-170

With the wide deployment of Wireless Local Area Network (WLAN), the WLAN Received Signal Strength (RSS) based indoor mapping has attracted significant attention for various of Location-based Services (LBSs). In this paper, we propose a new simultaneous pathway mapping and behavior understanding approach by crowdsourced sensing of WLAN RSS. First of all, a batch of WLAN RSS sequences with known locations...

article

Involvement of caveolin-1 in low shear stress-induced breast cancer cell motility and adhesion: Roles of FAK/Src and ROCK/p-MLC pathways

Niya Xiong, Shun Li, Kai Tang, Hongxia Bai, more

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2017 > 1864 > 1 > 12-22

Tumor cells translocating to distant sites are subjected to hemodynamic shear forces during their passage in the blood vessels. Low shear stress (LSS) plays a critical role in the regulation of various aspects of tumor cells functions, including motility and adhesion. Beyond its structural role, caveolin-1 (Cav-1), the important component of caveolae, represents a modulator of several cancer-associated...

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INFONA - science communication portal

Search results for: Yiyao Liu

Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy

Rigid linker peptides improve the stability and anti‐inflammation effect of human serum albumin and α‐melanocyte‐stimulating hormone fusion proteins

Biomimetic Nano‐Immunoactivator via Ionic Metabolic Modulation for Strengthened NIR‐II Photothermal Immunotherapy

Characterization of the role of TMEM175 in an in vitro lysosomal H⁺ fluxes model

CoNPR1 and CoNPR3.1 are involved in SA‐ and MeSA‐ mediated growth of the pollen tube in Camellia oleifera

Shear stress promotes anoikis resistance of cancer cells via caveolin‐1‐dependent extrinsic and intrinsic apoptotic pathways

New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure

Terahertz Electric Field-Induced Membrane Electroporation by Molecular Dynamics Simulations

Folate-targeted fluorescent nanomicelles co-loaded with elacridar and doxorubicin for overcoming multi-drug resistance and tumor imaging

Co-delivery of doxorubicin and P-glycoprotein siRNA using pH-sensitive PLGA nanobubbles for synergistic tumor therapy

Co-delivery of photosensitizer and toll-like receptor ligands via pH triggered charge-reversal polyelectrolyte-functionalized graphene for enhanced cancer photoimmunotherapy

Emerging roles of long non‐coding RNAs in the toxicology of environmental chemicals

Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway

Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses

Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy

Magnetic/fluorescent hybrid PLGA nanoparticles for doxorubicin/VEGF siRNA co-delivery and tumor imaging

pH-triggered mesoporous silica nanocomplexes for imaging-guided drug delivery with enhanced cancer therapeutic efficiency

Single wavelength light-mediated, synergistic bimodal cancer photoablation and amplified photothermal performance by graphene/gold nanostar/photosensitizer theranostics

Simultaneous pathway mapping and behavior understanding with crowdsourced sensing in WLAN environment

Involvement of caveolin-1 in low shear stress-induced breast cancer cell motility and adhesion: Roles of FAK/Src and ROCK/p-MLC pathways

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