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The gene-specific induction and removal of 8-methoxypsoralen (8-MOP) plus UVA-induced interstrand cross-links (ICL) was studied using the genetic system MATα and HMLα in Saccharomyces cerevisiae. We first examined events in a SIRα haploid strain (K107) in which these identical sequences are respectively transcriptionally active (MATα) and inactive (HMLα). Induction and repair of ICL was then studied...
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