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We report on the role of vpu in the pathogenesis of a molecularly cloned simian-human immunodeficiency virus (SHIV KU-1bMC33 ), in which the tat, rev, vpu, env, and nef genes derived from the uncloned SHIV KU-1b virus were inserted into the genetic background of parental nonpathogenic SHIV-4. A mutant was constructed (ΔvpuSHIV KU-1bMC33 ) in which 42 of 82 amino acids of Vpu...
Previously, we described the derivation of a pathogenic strain of simian–human immunodeficiency virus (SHIV KU-2 ) consisting of the tat, rev, vpu, and env genes of HIV-1 (strain HXB2) in a genetic background of SIV mac 239 that causes AIDS and productive infection of the CNS in rhesus macaques (Macca mulatta) (Raghavan et al., 1997, Brain Pathol. 7, 851–861). We report here on the...
A chimeric simian-human immunodeficiency virus (SHIV-4) containing thetat, rev, vpu,andenvgenes of HIV type 1 (HIV-1) in a genetic background of SIV mac 239 was used to develop an animal model in which a primate lentivirus expressing the HIV-1 envelope glycoprotein caused acquired immune deficiency syndrome (AIDS) in macaques. An SHIV-infected pig-tailed macaque that died from AIDS at 24 weeks...
Recently, we developed a highly pathogenic variant of simian–human immunodeficiency virus, SHIV-4 (containing thetat, rev, vpu,andenvof the HXB2 strain of HIV-1 in a genetic background of SIV mac 239), through a series of four bone marrow-bone marrow passages—first in rhesus monkeys and then in pig-tailed macaques [Joaget al. (1996) J. Virol.70, 3189–3197]. Inoculation of pig-tailed macaques...