Search results for: Denis J. Murphy

Items from 1 to 20 out of 29 results

article

Female‐to‐male differential transcription patterns of miRNA‐mRNA networks in the livers of dioxin‐exposed mice

Nour Hammoudeh, Chadi Soukkarieh, Denis J. Murphy, Abdulsamie Hanano

Environmental Toxicology > 38 > 10 > 2310 - 2331

Non‐coding microRNAs (miRNAs) have important roles in regulating the expression of liver mRNAs in response to xenobiotic‐exposure, but their roles concerning dioxins such as TCDD (2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin) are less clear. This report concerns the potential implication of liver (class I) and circulating (class II) miRNAs in hepatotoxicity of female and male mice after acute exposure to TCDD...

article

Use of headspace–gas chromatography–ion mobility spectrometry to detect volatile fingerprints of palm fibre oil and sludge palm oil in samples of crude palm oil

Abrizah Othman, Kirstie A. Goggin, Noor Idayu Tahir, Emma Brodrick, more

BMC Research Notes > 2019 > 12 > 1 > 1-6

Objective The addition of residual oils such as palm fibre oil (PFO) and sludge palm oil (SPO) to crude palm oil (CPO) can be problematic within supply chains. PFO is thought to aggravate the accumulation of monochloropropanediols (MCPDs) in CPO, whilst SPO is an acidic by-product of CPO milling and is not fit for human consumption. Traditional targeted techniques to detect such additives are costly,...

article

Evolutionary, structural and functional analysis of the caleosin/peroxygenase gene family in the Fungi

Farzana Rahman, Mehedi Hassan, Abdulsamie Hanano, David A. Fitzpatrick, more

BMC Genomics > 2018 > 19 > 1 > 1-24

Background Caleosin/peroxygenases, CLO/PXG, (designated PF05042 in Pfam) are a group of genes/proteins with anomalous distributions in eukaryotic taxa. We have previously characterised CLO/PXGs in the Viridiplantae. The aim of this study was to investigate the evolution and functions of the CLO/PXGs in the Fungi and other non-plant clades and to elucidate the overall origin of this gene family. ...

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In silico characterization and expression profiling of the diacylglycerol acyltransferase gene family (DGAT1, DGAT2, DGAT3 and WS/DGAT) from oil palm, Elaeis guineensis

Rozana Rosli, Pek-Lan Chan, Kuang-Lim Chan, Nadzirah Amiruddin, more

Plant Science > 2018 > 275 > C > 84-96

The diacylglycerol acyltransferases (DGAT) (diacylglycerol:acyl-CoA acyltransferase, EC 2.3.1.20) are a key group of enzymes that catalyse the final and usually the most important rate-limiting step of triacylglycerol biosynthesis in plants and other organisms. Genes encoding four distinct functional families of DGAT enzymes have been characterised in the genome of the African oil palm, Elaeis guineensis...

article

Tumor Suppressors Status in Cancer Cell Line Encyclopedia

Dmitriy Sonkin, Mehedi Hassan, Denis J. Murphy, Tatiana V. Tatarinova

Molecular Oncology > 2013 > 7 > 4 > 791-798

Tumor suppressors play a major role in the etiology of human cancer, and typically achieve a tumor-promoting effect upon complete functional inactivation. Bi-allelic inactivation of tumor suppressors may occur through genetic mechanisms (such as loss of function mutation, copy number (CN) loss, or loss of heterozygosity (LOH)), epigenetic mechanisms (such as promoter methylation or histone modification),...

article

The dynamic roles of intracellular lipid droplets: from archaea to mammals

Denis J. Murphy

Protoplasma > 2012 > 249 > 3 > 541-585

During the past decade, there has been a paradigm shift in our understanding of the roles of intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have underpinned these advances, which are revealing much new information about these dynamic organelles. This review takes a comparative approach by examining recent work on LDs across the whole range of biological organisms...

article

Roles of a membrane-bound caleosin and putative peroxygenase in biotic and abiotic stress responses in Arabidopsis

Mark Partridge, Denis J. Murphy

Plant Physiology and Biochemistry > 2009 > 47 > 9 > 796-806

We report here the localisation and properties of a new membrane-bound isoform of caleosin and its putative role as a peroxygenase involved in oxylipin metabolism during biotic and abiotic stress responses in Arabidopsis. Caleosins are a family of lipid-associated proteins that are ubiquitous in plants and true fungi. Previous research has focused on lipid-body associated, seed-specific caleosins...

article

Molecular breeding strategies for the modification of lipid composition

Denis J. Murphy

In Vitro Cellular & Developmental Biology - Plant > 2006 > 42 > 2 > 89-99

Summary Lipids are key components of all living cells. Acyl lipids and sterols provide the matrix of the biological membranes that both define the boundaries of cells and organelles, and act as sites for the trafficking of molecules within and into/out of cells. Lipids are also important metabolic intermediates and the most efficient form of energy storage that is available to a cell. It is the latter,...

article

Conserved methionines in chloroplasts

Cecilia Sundby, Ulrika Härndahl, Niklas Gustavsson, Emma Åhrman, more

BBA - Proteins and Proteomics > 2005 > 1703 > 2 > 191-202

Heat shock proteins counteract heat and oxidative stress. In chloroplasts, a small heat shock protein (Hsp21) contains a set of conserved methionines, which date back to early in the emergence of terrestrial plants. Methionines M49, M52, M55, M59, M62, M67 are located on one side of an amphipathic helix, which may fold back over two other conserved methionines (M97 and M101), to form a binding groove...

article

Temporal and transient expression of olive enoyl-ACP reductase gene during flower and fruit development

Zaruhi P. Poghosyan, Katerina Giannoulia, Panagiotis Katinakis, Denis J. Murphy, more

Plant Physiology and Biochemistry > 2005 > 43 > 1 > 37-44

Enoyl-ACP reductase is a catalytic component of the fatty acid synthetase (FAS) type II system in plants that is involved in the de novo fatty acid biosynthesis in plastids. A cDNA encoding an enoyl-ACP reductase responsible for the removal of the trans-unsaturated double bonds to form saturated acyl-ACP has been isolated from a library made from ripening fruits of Olea europaea L. The predicted protein...

article

Isolation and characterisation of two divergent type 3 metallothioneins from oil palm, Elaeis guineensis

Siti Nor Akmar Abdullah, S.C. Cheah, Denis J. Murphy

Plant Physiology and Biochemistry > 2002 > 40 > 3 > 255-263

Two distinct class I, type 3 metallothionein-like genes, MT3-A and MT3-B, were isolated from the oil palm, Elaeis guineensis. The MT3-A gene was isolated by subtractive hybridisation from a cDNA library prepared from mesocarp tissue at 15 weeks after anthesis (waa). The MT3-A mRNA made up over 1% of total transcripts and was the most abundant gene product in this ripening fruit tissue. The MT3-B gene...

article

Biotechnology and the improvement of oil crops – genes, dreams and realities

Denis J. Murphy

Phytochemistry Reviews > 2002 > 1 > 1 > 67-77

During the past decade, there have been many optimistic claims concerning the potential of novel oil-based products from genetically engineered crops, particularly for the manufacture of a new generation of renewable, carbon-neutral, industrial materials. Such claims have been underpinned by an impressive series of scientific advances that have resulted in the isolation of genes encoding most of the...

article

The biogenesis and functions of lipid bodies in animals, plants and microorganisms

Denis J. Murphy

Progress in Lipid Research > 2001 > 40 > 5 > 325-438

article

The Brassica napus calcium-binding protein, caleosin, has distinct endoplasmic reticulum- and lipid body-associated isoforms

Inmaculada Hernandez-Pinzon, Kanu Patel, Denis J. Murphy

Plant Physiology and Biochemistry > 2001 > 39 > 7-8 > 615-622

Caleosins are a recently described class of plant and fungal EF-hand, calcium-binding proteins that have been reported variously as binding exclusively to lipid bodies or binding to both lipid bodies and the endoplasmic reticulum (ER). Separations on high-resolution tricine/SDS-PAGE gels show that in developing Brassica napus embryos there are two major isoforms of caleosin with respective relative...

article

Role of lipid bodies and lipid-body proteins in seeds and other tissues

Denis J. Murphy, Inmaculada Hernández-Pinzón, Kanu Patel

Journal of Plant Physiology > 2001 > 158 > 4 > 471-478

Lipid bodies are present in most plant cells and not just in storage tissues, such as seeds, as is often assumed. There is a growing number of proteins that are associated with lipid bodies in different plant tissues. In seeds, the most common class of lipid-body protein is the oleosins, which are found on the surfaces on lipid bodies in all desiccation tolerant plants but are absent from lipid bodies...

article

Shewry PR, Casey R, eds. 1999. Seed proteins. 883pp. Dordrecht: Kluwer. £315 (hardback).

Denis J. Murphy

Annals of Botany > 2000 > 86 > 2 > 434-435

article

Caleosins: Ca²⁺-binding proteins associated with lipid bodies

Henrik Næsted, Gitte I. Frandsen, Guang-Yuh Jauh, Immaculada Hernandez-Pinzon, more

Plant Molecular Biology > 2000 > 44 > 4 > 463-476

We have previously identified a rice gene encoding a 27 kDa protein with a single Ca²⁺-binding EF-hand and a putative membrane anchor. We report here similar genes termed caleosins, CLO, in other plants and fungi; they comprise a multigene family of at least five members in Arabidopsis (AtClo1–5). Northern hybridization demonstrated that AtClo2–4 mRNAs levels were low in various tissues, while AtClo...

article

Production of novel oils in plants

Denis J Murphy

Current Opinion in Biotechnology > 1999 > 10 > 2 > 175-180

We have now isolated the great majority of genes encoding enzymes of storage oil biosynthesis in plants. In the past two years, particular progress has been made with acyltransferases, ketoacyl-acyl carrier protein synthetases and with desaturases and their relatives. In some cases, these enzymes have been re-engineered to create novel products. Nevertheless, the single or multiple insertion of...

article

Developmental regulation and spatial expression of a plastidial fatty acid desaturase from Olea europaea

Zaruhi P. Poghosyan, Kosmas Haralampidis, Anna I. Martsinkovskaya, Denis J. Murphy, more

Plant Physiology and Biochemistry > 1999 > 37 > 2 > 109-119

Trienoic fatty acids are major components of chloroplast membranes and are also precursors of the oxylipins, such as methyl jasmonate, that play important roles in signal transduction pathways relating to plant development and responses to stress. A cDNA encoding a plastidial ω-3 fatty acid desaturase responsible for trienoic formation has been isolated from a library made from ripening fruits of...

article

Composition and role of tapetal lipid bodies in the biogenesis of the pollen coat of Brassica napus

Inmaculada Hernndez-Pinzn, Joanne H. E. Ross, Karen A. Barnes, Andrew P. Damant, more

Planta > 1999 > 208 > 4 > 588-598

Abstract. The composition of the two major lipidic organelles of the tapetum of Brassica napus L. has been determined. Elaioplasts contained numerous small (0.20.6m) lipid bodies that were largely made up of sterol esters and triacylglycerols, with monogalactosyldiacylglycerol as the major polar lipid. This is the first report in any species of the presence of non-cytosolic, sterol ester-rich, lipid...

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INFONA - science communication portal

Search results for: Denis J. Murphy

Female‐to‐male differential transcription patterns of miRNA‐mRNA networks in the livers of dioxin‐exposed mice

Use of headspace–gas chromatography–ion mobility spectrometry to detect volatile fingerprints of palm fibre oil and sludge palm oil in samples of crude palm oil

Evolutionary, structural and functional analysis of the caleosin/peroxygenase gene family in the Fungi

In silico characterization and expression profiling of the diacylglycerol acyltransferase gene family (DGAT1, DGAT2, DGAT3 and WS/DGAT) from oil palm, Elaeis guineensis

Tumor Suppressors Status in Cancer Cell Line Encyclopedia

The dynamic roles of intracellular lipid droplets: from archaea to mammals

Roles of a membrane-bound caleosin and putative peroxygenase in biotic and abiotic stress responses in Arabidopsis

Molecular breeding strategies for the modification of lipid composition

Conserved methionines in chloroplasts

Temporal and transient expression of olive enoyl-ACP reductase gene during flower and fruit development

Isolation and characterisation of two divergent type 3 metallothioneins from oil palm, Elaeis guineensis

Biotechnology and the improvement of oil crops – genes, dreams and realities

The biogenesis and functions of lipid bodies in animals, plants and microorganisms

The Brassica napus calcium-binding protein, caleosin, has distinct endoplasmic reticulum- and lipid body-associated isoforms

Role of lipid bodies and lipid-body proteins in seeds and other tissues

Shewry PR, Casey R, eds. 1999. Seed proteins. 883pp. Dordrecht: Kluwer. £315 (hardback).

Caleosins: Ca²⁺-binding proteins associated with lipid bodies

Production of novel oils in plants

Developmental regulation and spatial expression of a plastidial fatty acid desaturase from Olea europaea

Composition and role of tapetal lipid bodies in the biogenesis of the pollen coat of Brassica napus

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