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Bioengineering of functional lung tissue by using whole lung scaffolds has been proposed as a potential alternative for patients awaiting lung transplant. Previous studies have demonstrated that vascular resistance (Rv) could be altered to optimize the process of obtaining suitable lung scaffolds. Therefore, this work was aimed at determining how lung inflation (tracheal pressure) and perfusion (pulmonary...
The present study evaluated the effects of an intramuscular injection of Tityus serrulatus venom (TsV) (0.67μg/g) on lung mechanics and lung inflammation at 15, 30, 60 and 180min after inoculation. TsV inoculation resulted in increased lung elastance when compared with the control group (p<0.001); these values were significantly higher at 60min than at 15 and 180min (p<0.05). Resistive pressure...
In the present work we investigated the effects of Crotalus durissus terrificus venom (CdtV) on the pulmonary mechanic events [static and dynamic elastance, resistive (ΔP1) and viscoelastic pressures (ΔP2)] and histology after intramuscular injection of saline solution (control) or venom (0.6μg/g). The static and dynamic elastance values were increased significantly after 3h of venom inoculation,...
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