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The dopamine D 2 agonist bromocriptine has a long lasting, biphasic effect on locomotion, causing decreased activity during the first 60-90 min after the injection, followed by increased activity that peaks 90-180 min after the injection. In Experiment 1, repeated injections of 5.0 mg/kg bromocriptine produced rapid development of locomotor sensitization when rats were placed in activity chambers...
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