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To investigate the functional roles of DRα residues in T-cell recognition, 20 mutants of the DRα chain were constructed by site-directed mutagenesis. These DRα mutants were expressed with WT DR(β1 * 0701) on mouse L cells and used as APC for four DR7-restricted T-cell clones specific for rabies virus antigens. The results indicate that the DRα residues are differentially involved in recognition...
Many residues involved in polymorphic antibody-binding epitopes on class II molecules are located on the α-helix of DRβ chains. Although they have received less attention, residues in the peptide-binding groove and second domain of the DRβ chain may also be critical for polymorphic anti-DR antibody epitopes. In this study, we used transfectants expressing site-directed mutations at positions in...