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Heat shock proteins (HSPs) are chaperone proteins which protect living cells against injury-inducing stimuli. Dysregulated HSP expression has been observed in various disease conditions, including cancer. With use of a knockout and transgenic animal approach as well as with use of standard methods of HSP70 induction, i.e., thermal stress and arsenite administration, it has been shown that HSP70 protects...
Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell...
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