Search results for: Lucy Chai See Lum

Items from 1 to 13 out of 13 results

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Health‐related quality of life and developmental outcome of children on home mechanical ventilation in a developing country: A cross‐sectional study

Lay Teng Tan, Anna Marie Nathan, Subhashini Jayanath, Kah Peng Eg, more

Pediatric Pulmonology > 55 > 12 > 3477 - 3486

Background Provision of home mechanical ventilation (HMV) to children with chronic respiratory insufficiency enhances growth and quality of life. The hypothesis was that health‐related quality of life (HRQoL) and the development of these children were poorer than in healthy children. Objectives To determine the HRQoL and developmental outcome of children on HMV. Methods This cross‐sectional study...

article

Using clinical practice guidelines to manage dengue: a qualitative study in a Malaysian hospital

Alexandra Wharton-Smith, Judith Green, Ee Chin Loh, Alexander Gorrie, more

BMC Infectious Diseases > 2019 > 19 > 1 > 1-10

Background Malaysia has rising dengue incidence. World Health Organization clinical practice guidelines for managing dengue have been adapted by the Ministry of Health in Malaysia, with evidence of good awareness by clinicians. However, dengue mortality has not reduced. This study aimed to explore the challenges of dengue management for Medical Officers, with a particular focus on use of clinical...

article

Thirteen years of invasive and noninvasive home ventilation for children in a developing country: A retrospective study

Anna Marie Nathan, Hui Yan Loo, Jessie Anne de Bruyne, Kah Peng Eg, more

Pediatric Pulmonology > 52 > 4 > 500 - 507

Introduction Home ventilation (HV) for children is growing rapidly worldwide. The aim was to describe (1) the sociodemographic characteristics of children on HV and (2) the indications for, means and outcome of initiating HV in children from a developing country. Methodology This retrospective study included patients sent home on noninvasive or invasive ventilation, over 13 years, by the pediatric...

article

International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module

Víctor Daniel Rosenthal, Hail M. Al-Abdely, Amani Ali El-Kholy, Safa A Aziz AlKhawaja, more

American Journal of Infection Control > 2016 > 44 > 12 > 1495-1504

Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific.Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN)...

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Hemophagocytosis in dengue: Comprehensive report of six cases

Lian Huat Tan, Lucy Chai See Lum, Sharifah Faridah Syed Omar, Foong Kee Kan

Journal of Clinical Virology > 2012 > 55 > 1 > 79-82

Hemophagocytic syndrome is a potentially fatal disorder. It is being increasingly reported but remained under-recognized in dengue. Most reported cases were in association with plasma leakage and shock but multi-organ impairment was also observed. We describe the time-lines of 6 cases of confirmed dengue with varying severities of hemophagocytosis. All had persistent fever, cytopenia and elevated...

article

Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children

Lucy Chai See Lum, Charissa Fay Borja-Tabora, Robert F. Breiman, Timo Vesikari, more

Vaccine > 2010 > 28 > 6 > 1566-1574

Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35±7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower...

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A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children

Robert F. Breiman, W. Abdullah Brooks, Doli Goswami, Rosanna Lagos, more

Vaccine > 2009 > 27 > 40 > 5472-5479

Live attenuated influenza vaccine (LAIV) provides a useful tool to rapidly immunize populations in the developing world to prevent influenza outbreaks. In this noninferiority trial conducted in Asia and South America, where oral poliovirus vaccine (OPV) is still used, 2503 children aged 6 to <36 months with three polio immunizations were randomized to receive LAIV+OPV, placebo+OPV, or LAIV only...

article

Clinicians’ diagnostic practice of dengue infections

Chris Fook Sheng Ng, Lucy Chai See Lum, Noor Azina Ismail, Lian Huat Tan, more

Journal of Clinical Virology > 2007 > 40 > 3 > 202-206

Difficulties in the classification of dengue infection have been documented. Such difficulties could be due to the low awareness of the World Health Organization diagnostic guidelines among clinicians.To study the diagnostic practices of clinicians in classifying patients as dengue fever (DF) or dengue haemorrhagic fever (DHF)/dengue shock syndrome (DSS) at the time of discharge during an outbreak...

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Preventive transfusion in dengue shock syndrome-is it necessary?

Lucy Chai See Lum, Mohammad El-Amin Abdel-Latif, Adrian Yu Teik Goh, Patrick Wai Keong Chan, more

The Journal of Pediatrics > 2003 > 143 > 5 > 682-684

We compared 53 patients with dengue shock syndrome (DSS) who received preventive transfusions with 53 who did not. Significant differences in the development of pulmonary edema and length of hospitalization (P<.05) and none in hemorrhage (P=.136) were observed. Preventive transfusions did not produce sustained improvements in the coagulation status in DSS.

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Risk factors for hemorrhage in severe dengue infections

Lucy Chai See Lum, Adrian Yu Teik Goh, Patrick Wai Keong Chan, Abdel-Latif Mohd El-Amin, more

The Journal of Pediatrics > 2002 > 140 > 5 > 629-631

The purpose of this study was to identify the early indicators of hemorrhage in severe dengue infections in 114 patients; 24 patients had severe hemorrhage and 92 had no hemorrhage. The platelet counts were not predictive of bleeding. The duration of shock (OR, 2.11; 95% CI, 1.13 to 3.92; P = .019) and low-normal hematocrit at the time of shock (OR, 0.72; 95% CI, 0.55 to 0.95; P = .020) were risk...

article

Echovirus 7 associated encephalomyelitis

Lucy Chai See Lum, Kaw Bing Chua, Peter Charles McMinn, Adrian Yu Teik Goh, more

Journal of Clinical Virology > 2002 > 23 > 3 > 153 - 160

Background: Hand, foot, and mouth disease (HFMD) is endemic in Malaysia. In 1997, a large outbreak of enterovirus 71 (EV-71) associated HFMD resulted in 41 deaths due to severe left ventricular dysfunction and central nervous system infection with extensive damage to the medulla and pons. The clinical presentation in all these patients were rapid cardio-respiratory decompensation leading to cardiac...

article

Impact of 24 hour critical care physician staffing on case-mix adjusted mortality in paediatric intensive care

Adrian Yu-Teik Goh, Lucy Chai-See Lum, Mohd El-Amin Abdel-Latif

The Lancet > 2001 > 357 > 9254 > 445-446

The 24 h availability of intensive care consultants (intensivists) has been shown to improve outcomes in adult intensive care units (ICU) in the UK. We tested whether such availability would improve standardised mortality ratios when compared to out-of-hours cover by general paediatricians in the paediatric ICU setting of a medium-income developing country. The standardised mortality ratio (SMR) improved...

article

Adenovirus in EV71-associated hand, foot, and mouth disease

Lucy Chai See Lum, Kum Thong Wong, Sai Kit Lam, Kaw Bing Chua, more

The Lancet > 2000 > 355 > 9198 > 146-147

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