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The debate about the purpose (and uses) of studying diplomatic and international history are as old as the subject itself. This article traces the origins and development of diplomatic history as a specialized field within history as a wider discipline, before exploring more recent challenges to it. The article seeks to highlight both the scope for, and the opportunities to be found in, cross‐fertilization...
RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain unclear. In an unbiased screen in Drosophila for RBPs that genetically interact with TDP-43, we found that downregulation of the mRNA export factor Ref1 (fly orthologue to human ALYREF) mitigated TDP-43 induced toxicity. Further, Ref1 depletion...
The historian Lord Acton is best known as Lord Rosebery's choice for the Regius Chair of Modern History at Cambridge University in 1895. This outcome was not the inexorable culmination an historian's career. It was rather a form of compensation for the failure of Acton's earlier ambitions for political or public office. Drawing on hitherto largely untapped archival material this article re‐examines...
This study was undertaken with the aim of evaluating inter- and intraobserver variation on the pathophysiological interpretation of individual electromyographic (EMG) tests on muscles and nerve segments. Seven physicians from 6 European EMG laboratories independently interpreted 81 EMG studies comprising 735 muscle tests and 726 tests on nerve segments. Pathophysiological conclusions were inferred...
A prospective international evaluation of the knowledge-based expert system KANDID indicated differences in epidemiology, planning strategies and techniques among seven different EMG laboratories (Vingtoft et al. 1993). To obtain standardisation and improve the quality of the EMG examination knowledge about inter-laboratory differences is needed. ESTEEM (European Standardised Telematic Tool to Evaluate...
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