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Ataxin‐2 (ATXN2) is a eukaryotic RNA‐binding protein that is conserved from yeast to human. Genetic expansion of a poly‐glutamine tract in human ATXN2 has been implicated in several neurodegenerative diseases, likely acting through gain‐of‐function effects. Emerging evidence, however, suggests that ATXN2 plays more direct roles in neural function via specific molecular and cellular pathways. ATXN2...
ATAXIN-2 (ATX2) has been implicated in human neurodegenerative diseases, yet it remains elusive how ATX2 assembles specific protein complexes to execute its physiological roles. Here we employ the posttranscriptional co-activator function of Drosophila ATX2 to demonstrate that LSM12 and ME31B/DDX6 are two ATX2-associating factors crucial for sustaining circadian rhythms. LSM12 acts as a molecular...
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