H.B. Pollard

article

Annexin 7 mobilizes calcium from endoplasmic reticulum stores in brain

W.D. Watson, M. Srivastava, X. Leighton, M. Glasman, more

BBA - Molecular Cell Research > 2004 > 1742 > 1-3 > 151-160

Mobilization of intracellular calcium from inositol-1,4,5-triphosphate (IP3)-sensitive endoplasmic reticulum (ER) stores plays a prominent role in brain function. Mice heterozygous for the annexin A7 (Anx7) gene have a profound reduction in IP3 receptor function in pancreatic islets along with defective insulin secretion. We examined IP3-sensitive calcium pools in the brains of Anx7 (+/−) mice by...

article

Cyclic 3′-5′-adenosine monophosphate binds to annexin I and regulates calcium-dependent membrane aggregation and ion channel activity

B.E. Cohen, G. Lee, N. Arispe, H.B. Pollard

FEBS Letters > 1995 > 377 > 3 > 444-450

The annexin (Anx) gene family comprises a set of calcium-dependent membrane binding proteins, which have been implicated in a wide variety of cellular processes including membrane fusion and calcium channel activity. We report here that cAMP activates Ca ²⁺ -dependent aggregation of both phosphatidylserine (PS) liposomes and bovine chromaffin granules driven by [des 1–12]annexin I (lipocortin...

article

Theoretical models of the ion channel structure of amyloid beta-protein

S.R. Durell, H.R. Guy, N. Arispe, E. Rojas, more

Biophysical Journal > 1994 > 67 > 6 > 2137-2145

Theoretical methods are used to develop models for the ion channel structure of the membrane-bound amyloid beta-protein. This follows recent observations that the beta-protein forms cation-selective channels in lipid bilayers in vitro. Amyloid beta-protein is the main component of the extracellular plaques in the brain that are characteristic of Alzheimer's disease. Based on the amino acid sequence...

article

A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the "three-halves (3/2) rule"

J.R. Pollard, N. Arispe, E. Rojas, H.B. Pollard

Biophysical Journal > 1994 > 67 > 2 > 647-655

Ion channels can express multiple conductance levels that are not integer multiples of some unitary conductance, and that interconvert among one another. We report here that for 26 different types of multiple conductance channels, all allowed conductance levels can be calculated accurately using the geometric sequence gn = g(o) (3/2)n, where gn is a conductance level and n is an integer > or =...

article

Calcium channel and membrane fusion activity of synexin and other members of the Annexin gene family

H.B. Pollard, H.R. Guy, N. Arispe, M. de la Fuente, more

Biophysical Journal > 1992 > 62 > 1 > 15-18

article

Monoclonal antibodies against the presynaptic calcium channel antagonist ω-conotoxin GVI A from cone snail poison

D. Tombaccini, O.M. Adeyemo, H.B. Pollard, G. Feuerstein

FEBS Letters > 1990 > 261 > 1 > 71-75

Monoclonal antibodies have been prepared against co-conotoxin GVI A, a peptide isolated from marine snails of the genus Conus (Conus geographus and Conus magus). This toxin is a blocker of select presynaptic Ca ² ⁺ channels in the central nervous system. Antigenic ω-conotoxin GVI A was synthesized as a covalent conjugate with bovine serum albumin and injected s.c. An ELISA assay combined...

article

A biophysical model of the chromaffin granule. Accurate description of the kinetics of ATP and Cl- dependent granule lysis

C.E. Creutz, H.B. Pollard

Biophysical Journal > 1980 > 31 > 2 > 255-270

A model is constructed to describe the behavior of isolated chromaffin granules (secretory vesicles of the adrenal medulla) when they are induced to release their contents by incubation with MgATP and Cl-. The model is based on the assumption that the release event is osmotic lysis due to the ATPase dependent influx of protons and osmotically active Cl- ions. The consequences of this influx of osmotically...

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Search results for: H.B. Pollard

Annexin 7 mobilizes calcium from endoplasmic reticulum stores in brain

Cyclic 3′-5′-adenosine monophosphate binds to annexin I and regulates calcium-dependent membrane aggregation and ion channel activity

Theoretical models of the ion channel structure of amyloid beta-protein

A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the "three-halves (3/2) rule"

Calcium channel and membrane fusion activity of synexin and other members of the Annexin gene family

Monoclonal antibodies against the presynaptic calcium channel antagonist ω-conotoxin GVI A from cone snail poison

A biophysical model of the chromaffin granule. Accurate description of the kinetics of ATP and Cl- dependent granule lysis

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INFONA - science communication portal

Search results for: H.B. Pollard

Annexin 7 mobilizes calcium from endoplasmic reticulum stores in brain

Cyclic 3′-5′-adenosine monophosphate binds to annexin I and regulates calcium-dependent membrane aggregation and ion channel activity

Theoretical models of the ion channel structure of amyloid beta-protein

A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the "three-halves (3/2) rule"

Calcium channel and membrane fusion activity of synexin and other members of the Annexin gene family

Monoclonal antibodies against the presynaptic calcium channel antagonist ω-conotoxin GVI A from cone snail poison

A biophysical model of the chromaffin granule. Accurate description of the kinetics of ATP and Cl- dependent granule lysis

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