Search results for: Giampiero Ferraguti

Items from 1 to 8 out of 8 results

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Fetus morphology changes by second‐trimester ultrasound in pregnant women drinking alcohol

Giampiero Ferraguti, Lucia Merlino, Gemma Battagliese, Maria Grazia Piccioni, more

Fetal alcohol spectrum disorders (FASDs) are a group of negative conditions occurring in children exposed to alcohol during gestation. The early discovery of FASD is crucial for mother and infant follow‐ups. In this study, we investigated in pregnant women the association between urine ethylglucuronide (EtG—a biomarker of alcohol drinking) and indicators of the physical characteristics of FASD by...

article

Abstracts from the 23rd Italian congress of Cystic Fibrosis and the 13th National congress of Cystic Fibrosis Italian Society

Annamaria Bevivino, Alessandra Coiana, Annalisa Fogazzi, Fabiana Timelli, more

Italian Journal of Pediatrics > 2018 > 44 > 1 > 1-23

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Ethylglucuronide in the urine as a marker of alcohol consumption during pregnancy: Comparison with four alcohol screening questionnaires

Giampiero Ferraguti, Paola Ciolli, Valentina Carito, Gemma Battagliese, more

Toxicology Letters > 2017 > 275 > C > 49-56

Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strategies to reveal alcohol use have been planning including the use of screening questionnaires...

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The Impact on Genetic Testing of Mutational Patterns of CFTR Gene in Different Clinical Macrocategories of Cystic Fibrosis

Marco Lucarelli, Sabina M. Bruno, Silvia Pierandrei, Giampiero Ferraguti, more

The Journal of Molecular Diagnostics > 2016 > 18 > 4 > 554-565

More than 2000 sequence variations of the cystic fibrosis transmembrane conductance regulator gene are known. The marked genetic heterogeneity, poor functional characterization of the vast majority of sequence variations, and an uncertain genotype-phenotype relationship complicate the definition of mutational search strategies. We studied the effect of the marked genetic heterogeneity detected in...

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Paternal alcohol exposure in mice alters brain NGF and BDNF and increases ethanol‐elicited preference in male offspring

Mauro Ceccanti, Roberto Coccurello, Valentina Carito, Stefania Ciafrè, more

Addiction Biology > 21 > 4 > 776 - 787

Ethanol (EtOH) exposure during pregnancy induces cognitive and physiological deficits in the offspring. However, the role of paternal alcohol exposure (PAE) on offspring EtOH sensitivity and neurotrophins has not received much attention. The present study examined whether PAE may disrupt nerve growth factor (NGF) and/or brain‐derived neurotrophic factor (BDNF) and affect EtOH preference/rewarding...

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A Genotypic-Oriented View of CFTR Genetics Highlights Specific Mutational Patterns Underlying Clinical Macrocategories of Cystic Fibrosis

Marco Lucarelli, Sabina Maria Bruno, Silvia Pierandrei, Giampiero Ferraguti, more

Molecular Medicine > 2014 > 21 > 1 > 257-275

Cystic fibrosis (CF) is a monogenic disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The genotype-phenotype relationship in this disease is still unclear, and diagnostic, prognostic and therapeutic challenges persist. We enrolled 610 patients with different forms of CF and studied them from a clinical, biochemical, microbiological and genetic point...

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A 96-well formatted method for exon and exon/intron boundary full sequencing of the CFTR gene

Marco Lucarelli, Lorena Narzi, Rita Piergentili, Giampiero Ferraguti, more

Analytical Biochemistry > 2006 > 353 > 2 > 226-235

Full genotypic characterization of subjects affected by cystic fibrosis (CF) is essential for the definition of the genotype–phenotype correlation as well as for the enhancement of the diagnostic and prognostic value of the genetic investigation. High-sensitivity diagnostic methods, capable of full scanning of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, are needed to enhance...

article

Effects of different oxidizing agents on neutral amino acid transport systems in isolated bovine brain microvessels

Patrizia Cardelli, Sigfrido Scarpa, Fabrizio Ceci, Marco Lucarelli, more

Neurochemistry International > 2002 > 41 > 1 > 29-36

Using isolated bovine brain microvessels as an in vitro model of the blood-brain barrier (BBB) we have evaluated the role of free radical generating solutions on some amino acid transport systems operating on the endothelial cell membrane. Fe ² ⁺ /ascorbate, phenylhydrazine and CuSO ₄ did not affect any of the transport system tested, while exposure of bovine brain microvessels...

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