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Cancer associated fibroblasts (CAFs) constitute an abundant stromal component of most solid tumors. Fibroblast activation protein (FAP) α is a cell surface protease that is expressed by CAFs. We corroborate this expression profile by immunohistochemical analysis of colorectal cancer specimens. To better understand the tumor-contextual role of FAPα, we investigate how FAPα shapes functional and proteomic...
The aim of the study was to investigate the mRNA expression levels of IGF1, IGF1R, and SP1 in cervical epithelial cells in different stages of cervical cancerogenesis using real-time PCR. The analysis indicated up-regulation of IGF1 gene expression in L- SIL and H-SIL, followed by its down-regulation in cervical cancer. Firstly, the obtained results suggest that IGF1 can be recognised asan essential...
Human papillomaviruses (HPVs) are a large group, with over 100 genotypes, of small nonenveloped, double-stranded DNA viruses. HPV types may be classified by infection location on the body each virus tends to infect and its potential for oncogenesis. ?High-risk' and ?low-risk' nomenclature was proposed for HPV genotypes (HPV-HR and HPV-LR). HPV is the major etiologic factor in cervical cancer and is...
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