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Cardiac myocyte excitation-contraction coupling (ECC, Table 1) is an intricate process by which many proteins and substances interact to form a complex but well-tuned system. The regulation of this system is essential to modulation of contractile activity.
The Ca 2+ concentration inside the sarcoplasmic reticulum ([Ca 2+ ] SR ) is a difficult parameter to measure in ventricular cardiac myocytes. Interference from Ca 2+ -sensitive dye loading into cellular compartments other than the SR interferes with free Ca 2+ measurement. In addition, the composition of the cytosol surrounding the SR in intact cells cannot...
To measure the free intrasarcoplasmic reticulum [Ca] ([Ca]SR) in isolated rat cardiac microsomes, ventricular tissue was homogenized in the presence of the low-affinity Ca indicator furaptra. Stepwise increases in cuvette [Ca] ([Ca]c) in the presence of ATP caused progressive increases in steady-state intravesicular fluorescence ratio to a maximum (Rmax). Steady-state [Ca]SR/[Ca]c was approximately...
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