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We investigated the association between genetic polymorphisms (GPs) in immune response genes and CMV viremia and disease in lung transplant (LT) recipients that are both CMV sero-positive (R+) and recipient negative/donor positive (R−/D+).CMV viremia and disease were determined in a cohort of LTx (n=389) that included 62% (R+), 20% (R−/D+), and 17% (R−/D−). All LTx were analysed for9 GPs:5 cytokines...
Background. Cytomegalovirus (CMV) disease continues to be a major problem for lung transplant patients who generate an inefficient immune response to control this viral infection. Both T helper and cytotoxic T cells are thought to play an important role in prevention and control of CMV disease. We investigated the clinical significance of CMV-specific memory responses in lung transplant recipients...