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Human cathelicidin LL‐37 protects against infections and endotoxin‐induced inflammation. In a recent study we have shown that IG‐19, an LL‐37‐derived peptide, protects in a murine model of arthritis. Cytokine interleukin‐32 (IL‐32) is elevated and directly associated with the disease severity of inflammatory arthritis. Therefore, in this study we examined the effects of LL‐37 and IG‐19 on IL‐32‐induced...
Current therapies for autoimmune chronic inflammatory diseases e.g. rheumatoid arthritis (RA) include inhibitors of inflammatory cytokines. However, these therapies can result in increased risk of infections. There is a need to explore alternate strategies that can control inflammation without compromising the innate ability to resolve infections. In this study, we examined the effect of small peptides...
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