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Fibroblasts degrade about 15% of newly synthesised collagen within the cell before it can be secreted. When the helical structure of collagen is disrupted, about 30% is degraded intracellularly. To determine if collagen degradation occurs in a pre-lysosomal compartment, the passage of type I collagen out of the endoplasmic reticulum or Golgi was inhibited by incubating human lung fibroblasts with...