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SNARE proteins constitute the core of the exocytotic membrane fusion machinery. Fusion occurs when vesicle‐associated and target membrane‐associated SNAREs zipper into trans‐SNARE complexes (‘SNAREpins’), but the number required is controversial and the mechanism of cooperative fusion is poorly understood. We developed a highly coarse‐grained molecular dynamics simulation to access the long fusion...
Understanding how functional lipid domains in live cell membranes are generated has posed a challenge. Here, we show that transbilayer interactions are necessary for the generation of cholesterol-dependent nanoclusters of GPI-anchored proteins mediated by membrane-adjacent dynamic actin filaments. We find that long saturated acyl-chains are required for forming GPI-anchor nanoclusters. Simultaneously,...
The molecular mechanism of ethanol and its effects on neurological function is far from clear. In this study, we investigate the effects of ethanol on various structural and dynamical properties of mixed bilayers consisting of different ratios of dipalmitoylphosphatidylcholine (DPPC), sphingomyelin (SM) and cholesterol that are typical constituents of neural cell membranes (Calderon et al., 1995)...
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