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Interactions between live Entamoeba invadens trophozoites and guinea-pig caecal explants were studied. A high percentage of amoebae adhering to the apical surface of epithelial cells was observed 10-20 min after infection, but no histopathological changes were observed. After 30 min, mild oedema at the base of the interglandular epithelium and death of some epithelial cells were evident. The epithelial...