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The process of post-replicative DNA-mismatch repair seems to be highly evolutionarily conserved. In Escherichia coli, DNA mismatches are recognized by the MutS protein [1,2]. Homologues of the E. coli mutS and mutL mismatch-repair genes have been identified in other prokaryotes, as well as in yeast and mammals (see [3] for review). Recombinant Saccharomyces cerevisiae MSH2 (MSH for MutS homologue)...
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