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The present study was designed: (1) to investigate the effects of the inducing agents phenobarbital (PB), 3-methyl cholanthrene (3-MC), and rifampicin (RFP) on paraoxonase (POX) and arylesterase (ARE) in liver and plasma, using the rat as model; and (2) to determine whether the response of both esterase activities to inducers is similar each one or, on the contrary, they are different enzymes. If...
Humans are exposed to a range of xenobiotic esters used as pesticides. Hydrolysis by esterases present in liver microsomes, cytosol and blood is a major route for the detoxification of xenobiotic esters in humans. We have studied the subcellular localization and some biochemical properties of human liver paraoxonase in order to establish a correlation with serum enzyme and the relative importance...
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