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The transcription factor Brinker (Brk) represses gene expression in the Drosophila wing imaginal disc, where it is expressed in symmetrical lateral-to-medial gradients, a pattern that is established by inverse gradients of the TGF-β, Dpp, which is in turn transduced into graded phosphorylated Mad (pMad, an R-Smad). pMad is part of a complex which directly represses brk. sal and omb are targets of...
The distal region of the Drosophila leg, the tarsus, is divided into five segments (ta I–V) and terminates in the pretarsus, which is characterized by a pair of claws. Several homeobox genes are expressed in distinct regions of the tarsus, including aristaless (al) and lim1 in the pretarsus, Bar (B) in ta IV and V, and apterous (ap) in ta IV. This pattern is governed by regulatory interactions between...
Dpp, a TGFβ, organizes pattern in the Drosophila wing by acting as a graded morphogen, activating different targets above distinct threshold concentrations. Like other TGFβs, Dpp appears to induce transcription directly via activation of a SMAD, Mad. However, here we demonstrate that Dpp can also control gene expression indirectly by down regulating the expression of the brinker gene, which encodes...
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