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Ghrelin circulates as acylated (AG) and unacylated (or desacyl) ghrelin (UAG). We aimed at clarifying the effect of age and sex on plasma deacylation and degradation of AG in vivo and in vitro in the rat. In vivo, we compared AG and UAG concentrations following administration of 1μg AG intraperitoneally in rat neonates during the first 3h of life. AG administration caused a 2–3 times increase in plasma...
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