Pradip Chaudhari

article

ERBB2 and KRAS alterations mediate response to EGFR inhibitors in early stage gallbladder cancer

Prajish Iyer, Shailesh V. Shrikhande, Malika Ranjan, Asim Joshi, more

International Journal of Cancer > 144 > 8 > 2008 - 2019

The uncommonness of gallbladder cancer in the developed world has contributed to the generally poor understanding of the disease. Our integrated analysis of whole exome sequencing, copy number alterations, immunohistochemical, and phospho‐proteome array profiling indicates ERBB2 alterations in 40% early‐stage rare gallbladder tumors, among an ethnically distinct population not studied before, that...

article

Multiple layer formation of bovine serum albumin on silver nanoparticles revealed by dynamic light scattering and spectroscopic techniques

Manik Waghmare, Bipin Khade, Pradip Chaudhari, Prabhakar Dongre

Journal of Nanoparticle Research > 2018 > 20 > 7 > 1-21

It is well known that when nanoparticles (NPs) are exposed to biological fluid, it results into formation of nanoparticle protein corona, which has been the subject of extensive studies for the development of targeted drug delivery. In this work, we demonstrated the dynamic light scattering, fluorescence, and UV-visible spectroscopy as quantitative and qualitative tools to monitor adsorption of BSA...

article

Osteogenic Nanofibrous Coated Titanium Implant Results in Enhanced Osseointegration: In Vivo Preliminary Study in a Rabbit Model

Siddhartha Das, Sandeep Gurav, Vivek Soni, Arvind Ingle, more

Tissue Engineering and Regenerative Medicine > 2018 > 15 > 2 > 231-247

A titanium implant surface when coated with biodegradable, highly porous, osteogenic nanofibrous coating has shown enhanced intrinsic osteoinductive and osteoconductive properties. This coating mimics extracellular matrix resulting in differentiation of stem cells present in the peri-implant niche to osteoblast and hence results in enhanced osseointegration of the implant. The osteogenic nanofibrous...

article

Improved method for preparing Ni(II) complex of (S)-tyrosine Schiff base and its use in the automated synthesis of O-(2′-[18F]fluoroethyl)-l-tyrosine using solid-phase extraction purification

N. Lakshminarayanan, Amit Kumar, Sushant Roy, Yogita Pawar, more

Applied Radiation and Isotopes > 2017 > 127 > C > 122-129

O-(2′-[¹⁸F]fluoroethyl)-l-tyrosine is reportedly suitable for PET-imaging of brain tumours. We report here the synthesis of Ni(II)-complex of Schiff's base (S)-[N-2-(N′-benzylprolyl)amino]-benzophenone,((S)BPB) and alkylated l-tyrosine precursor, Ni(II)-(S)-BPB-l-Tyr-O-CH₂-CH₂-OTs by an improved method. A fully-automated radio-synthesis including non-HPLC purification was developed with a radio-chemical...

article

Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling

Dinesh Thummuri, V. G. M. Naidu, Pradip Chaudhari

Journal of Molecular Medicine > 2017 > 95 > 10 > 1065-1076

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor, which plays an important role in the cellular defense against oxidative stress by induction of anti-oxidant and cytoprotective enzymes. In the current study, we sought to investigate the osteoprotective effect of carnosic acid (CA), a phenolic (catecholic) diterpene. It is widely identified for its electrophilic...

article

Safety and bioactivity studies of Jasad Bhasma and its in-process intermediate in Swiss mice

Aparna Chavare, Praneeth Chowdari, Sandipto Ghosh, Priyanka Pawar, more

Journal of Ethnopharmacology > 2017 > 197 > C > 73-86

Bhasma, Ayurvedic medicinal preparations, are prepared using herbs and minerals on following long iterative procedures. However, industrially mercury and sulphur are more commonly used to prepare bhasma from its raw material. The end point of this iterative procedure is mainly judged by the traditional tests specifying physical appearance of the powders. They fail to give better idea about chemical...

article

Design of cholesterol arabinogalactan anchored liposomes for asialoglycoprotein receptor mediated targeting to hepatocellular carcinoma: In silico modeling, in vitro and in vivo evaluation

Pankaj Pathak, Vivek Dhawan, Aniket Magarkar, Reinis Danne, more

International Journal of Pharmaceutics > 2016 > 509 > 1-2 > 149-158

We have developed active targeting liposomes to deliver anticancer agents to ASGPR which will contribute to effective treatment of hepatocellular carcinoma. Active targeting is achieved through polymeric ligands on the liposome surface. The liposomes were prepared using reverse phase evaporation method and doxorubicin hydrocholoride, a model drug, was loaded using the ammonium sulphate gradient method...

article

Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent

Chanda Arjun, Archana Mukherjee, Jyotsna Bhatt, Pradip Chaudhari, more

Applied Radiation and Isotopes > 2016 > 107 > C > 8-12

The aim of this study was to formulate an indigenous cold kit of Ubiquicidin, UBI (29-41), for easy preparation of ^99mTc-UBI (29-41) to be used as an infection imaging agent. A two component kit with the peptide and SnCl₂ as vial 1 and optimum amount of NaOH as vial 2 was successfully formulated as seen from the consistent radiochemical and pharmaceutical purity of the product over six consecutive...

article

Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling

Dinesh Thummuri, Manish Kumar Jeengar, Shweta Shrivastava, Harishankar Nemani, more

Pharmacological Research > 2015 > 99 > Complete > 63-73

Osteoclasts are multinuclear giant cells responsible for bone resorption in inflammatory bone diseases such as osteoporosis, rheumatoid arthritis and periodontitis. Because of deleterious side effects with currently available drugs the search continues for novel effective and safe therapies. Thymoquinone (TQ), the major bioactive component of Nigella sativa has been investigated for its anti-inflammatory,...

article

Fabrication and characterization of silicon based thermal neutron detector with hot wire chemical vapor deposited boron carbide converter

Pradip Chaudhari, Arvind Singh, Anita Topkar, Rajiv Dusane

Nuclear Instruments and Methods in Physics Research Section A: Accelerators,... > 2015 > 779 > C > 33-38

In order to utilize the well established silicon detector technology for neutron detection application, a silicon based thermal neutron detector was fabricated by integrating a thin boron carbide layer as a neutron converter with a silicon PIN detector. Hot wire chemical vapor deposition (HWCVD), which is a low cost, low temperature process for deposition of thin films with precise thickness was explored...

article

Development of ⁶⁸Ga‐labeled fatty acids for their potential use in cardiac metabolic imaging

Akanksha Jindal, Anupam Mathur, Usha Pandey, H. D. Sarma, more

Journal of Labelled Compounds and Radiopharmaceuticals > 57 > 7 > 463 - 469

While [¹¹C]palmitate continues to be a promising tracer for cardiovascular Positron Emission Tomography (PET) imaging, unfavourable logistics due to the short half‐life of ¹¹C (20 min) and cumbersome labeling methodologies are the major impediments that limit its widespread use. In order to circumvent such limitations, an attempt has been made to explore the potential of ⁶⁸Ga‐labeled fatty acid analogs...

article

Hot wire chemical vapor deposited boron carbide thin film/crystalline silicon diode for neutron detection application

Pradip Chaudhari, Arvind Singh, Anita Topkar, Rajiv Dusane

Solid State Electronics > 2012 > 78 > Complete > 156-158

Boron carbide films have been deposited on n-type crystalline silicon substrate by hot wire chemical vapor deposition technique using ortho-carborane precursor. The deposited films have been characterized by secondary ion mass spectrometry for their isotopic study which shows the presence of ¹⁰ B in the film making them suitable for thermal neutron absorber application. These films have a...

chapter

Hot wire chemical vapor deposited boron carbide thin film/c-silicon diode for neutron detection application

Pradip Chaudhari, Arvind Singh, Anita Topkar, Rajiv Dusane

2011 International Semiconductor Device Research Symposium (ISDRS) > 1 - 2

2011 International Semiconductor Device Research Symposium (ISDRS)

The Boron carbide (BC) is an interesting material due to its chemical and mechanical properties like extremely hard and wear-resistant material, high melting point, low density, good thermal and electrical properties, and great resistance to chemical agents. It has very high neutron absorption cross-section area and makes boron carbide a strong candidate for high technology industries, fast-breeders,...

chapter

Process engineering to avoid epitaxy at a-Si:H/c-Si interface for heterojunction silicon solar cells

Shahaji More, Pradip Chaudhari, R. O. Dusane

2011 International Semiconductor Device Research Symposium (ISDRS) > 1 - 2

2011 International Semiconductor Device Research Symposium (ISDRS)

Due to excellent surface passivation achieved by the overlying hydrogenated amorphous silicon (a-Si:H) layer which yields very high efficiency solar cells[1], the heterojunction silicon solar cells concept offers a possibility of reducing the total cost of PV production to an acceptable value for commercial viability and fulfill world's energy needs. The HIT solar cell performance has significantly...

article

Hot wire chemical vapour deposition (HWCVD) of boron carbide thin films from ortho-carborane for neutron detection application

Pradip Chaudhari, Nagsen Meshram, Arvind Singh, Anita Topkar, more

Thin Solid Films > 2011 > 519 > 14 > 4561-4564

Detection of neutrons is possible if suitable converters such as Li, LiF or ¹⁰ B in the form of thin films are used along with the semiconductor device. The use of boron ( ¹⁰ B) in some host matrix as a neutron detector is attractive due to its large neutron capture cross-section. Boron carbide (BC) films are deposited on silicon substrates by HWCVD technique using solid ortho-carborane...

INFONA - science communication portal

Search results for: Pradip Chaudhari

ERBB2 and KRAS alterations mediate response to EGFR inhibitors in early stage gallbladder cancer

Multiple layer formation of bovine serum albumin on silver nanoparticles revealed by dynamic light scattering and spectroscopic techniques

Osteogenic Nanofibrous Coated Titanium Implant Results in Enhanced Osseointegration: In Vivo Preliminary Study in a Rabbit Model

Improved method for preparing Ni(II) complex of (S)-tyrosine Schiff base and its use in the automated synthesis of O-(2′-[18F]fluoroethyl)-l-tyrosine using solid-phase extraction purification

Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling

Safety and bioactivity studies of Jasad Bhasma and its in-process intermediate in Swiss mice

Design of cholesterol arabinogalactan anchored liposomes for asialoglycoprotein receptor mediated targeting to hepatocellular carcinoma: In silico modeling, in vitro and in vivo evaluation

Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent

Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling

Fabrication and characterization of silicon based thermal neutron detector with hot wire chemical vapor deposited boron carbide converter

Development of ⁶⁸Ga‐labeled fatty acids for their potential use in cardiac metabolic imaging

Hot wire chemical vapor deposited boron carbide thin film/crystalline silicon diode for neutron detection application

Hot wire chemical vapor deposited boron carbide thin film/c-silicon diode for neutron detection application

Process engineering to avoid epitaxy at a-Si:H/c-Si interface for heterojunction silicon solar cells

Hot wire chemical vapour deposition (HWCVD) of boron carbide thin films from ortho-carborane for neutron detection application

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