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Objective
Disruption of the DNA methylation pathway involving 5‐hydroxymethylcytosine (5hmC) has been implicated in hepatic tumour development. The aim of this study was to investigate the expression of 5hmC in malignant and benign hepatic mass lesions and evaluate the diagnostic utility of deficient 5hmC expression in hepatocellular carcinoma (HCC).
Methods
Our study consisted of 48 fine needle...
The efficacy of adjuvant interferon treatment for the management of patients with viral hepatitis‐related hepatocellular carcinoma (HCC) following curative treatment is controversial. We have conducted a systematic review with meta‐analysis to assess the effects of adjuvant interferon therapy on survival outcomes. Randomized and nonrandomized studies (NRSs) comparing adjuvant interferon treatment...
Hepatitis B virus (HBV) infection is associated with the development of acute and chronic liver diseases including hepatocellular carcinoma (HCC). T‐cell immunoglobulin domain and mucin domain‐containing molecule‐3 (Tim‐3), which negatively regulates T‐cell response and mediates phagocytosis of apoptotic cells, has been implicated in HBV infection and cancers. This study explored the polymorphisms...
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