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Objectives
National guidelines in Botswana recommend baseline CD4 count measurement and both CD4 and HIV viral load (VL) monitoring post‐antiretroviral therapy (ART) initiation. We evaluated the utility of CD4 count measurement in Botswana in the era of universal ART.
Methods
CD4 and VL data were analysed for HIV‐infected adults undergoing CD4 count measurement in 2015–2017 at the Botswana Harvard...
Control of inflammation at the maternal–fetal interface is a critical element in mammalian pregnancy. Previous work from our laboratory has shown that Stat3 may be a placental mediator involved in maintaining immunologic homeostasis at the maternal–fetal interface. The aim of the current study is to further elucidate the role of Stat3 in response to inflammation. As ablation of Stat3 in mice results...
Infection of the maternal vaginal tract is one of the single most important antecedents of premature labor. We have hypothesized that the abundant local synthesis of pro-inflammatory cytokines that occurs during infection may disrupt the delicate “immunological cross-talk” that must occur between maternal and fetal tissues in order to carry pregnancy to term. These experiments were undertaken as part...
This update focuses on new problems and advances in infectious diseases over the last two years. Several important emerging infections, the problem of drug resistance and increasing virulence in common pathogens, and the continuing challenge of tuberculosis, as both a global and local problem, will be discussed. Advances include new diagnostic strategies for tuberculosis, novel antimicrobial agents,...
Inflammatory mediators play critical physiologic roles throughout the course of normal pregnancy. At the same time, uncontrolled inflammation appears to have an adverse affect on pregnancy outcome. Thus, a crucial task of reproductive immunology is to define the mechanisms through which inflammation is controlled at the maternal–fetal interface. We examined the signaling pathways activated in the...
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