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Two isoforms of the androgen receptor (AR-A and AR-B), differing by a lack of the first 187 amino acids in the NH 2 -terminal transactivation domain of AR-A, are expressed in connective tissue and bone. Transient transfections of normal human osteoblastic cells (HOB) and of genital skin fibroblasts defective in AR (GSF-540) were utilized to compare the functional properties of AR isoforms...
We have investigated the mutagenic effects of ENU, a potent mutagen in mouse spermatogonia, and of the two postmeiotic germ cell mutagens MMS and iPMS in germ cells, using a transgenic mouse mutation assay (lacZ/MutaMouse, positive selection system). The test compounds were administered to 6-week-old animals by a single intraperitoneal injection. Seminiferous tubule germ cells were isolated from...
Experimental features of a positive selection transgenic mouse mutation assay based on a λlacZ transgene are considered in detail, with emphasis on results using germ cells as the target tissue. Sources of variability in the experimental protocol that can affect the statistical nature of the observations are examined, with the goal of identifying sources of excess variation in the observed mutant...
Experimental features of a positive selection transgenic mouse mutation assay based on a λlacZ transgene are considered in detail, with emphasis on results using germ cells as the target tissue. Sources of variability in the experimental protocol that can affect the statistical nature of the observations are examined, with the goal of identifying sources of excess variation in the observed mutant...
We have investigated the mutagenic effects of ENU, a potent mutagen in mouse spermatogonia, and of the two postmeiotic germ cell mutagens MMS and iPMS in germ cells, using a transgenic mouse mutation assay (lacZ/Muta TM Mouse, positive selection system). The test compounds were administered to 6-week-old animals by a single intraperitoneal injection. Seminiferous tubule germ cells were...
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