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Over the past 20 years, drug discovery programs focusing on the aberrant disease‐related proteins of the kinome have resulted in some of the most clinically significant small molecules. The enormous effort and success in producing potent inhibitors against these targets has laid the groundwork for more recent research into the design of inhibitors against more nontraditional targets of human disease...
This paper summarizes the results of a parametric study performed to enhance the understanding of some important characteristics of tuned mass dampers (TMD). The effect of detuning on some of the TMD parameters on the performance is studied using steady-state harmonic excitation analysis and time-history analysis. The El Centro and Mexico excitations are used for time-history analysis. The effects...
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