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Desmoid tumours (DT) are myofibroblastic proliferations found in 10–25% of familial adenomatous polyposis (FAP) patients, either intra-abdominally (IA), in the abdominal wall (AW) or elsewhere (extra-abdominal (EA)). Most DT occur following prophylactic colectomy but occasionally patients present with pre-operative DT. Mutations 3′ to codon 1444, predispose to DT and attenuated phenotype, leading...
PURPOSE In familial adenomatous polyposis, the long-term risk of pouch polyposis and potential for pouch cancer are unknown. Our aim was to evaluate prospectively the prevalence, nature, and etiology of pouch ileal adenomas with that of nonpouch ileal adenomas in familial adenomatous polyposis. METHODS Sixty patients with familial adenomatous polyposis pouch, 47 familial adenomatous polyposis patients...
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