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The relationship between central nervous system serotonergic activity, as reflected by cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and sleep/wakefulness behavior was investigated in socially housed, juvenile rhesus macaques. Two cohorts of rhesus monkeys (Macaca mulatta), numbering 42 subjects (seventeen 39-month-olds and twenty-five 20-month-olds)...