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Granulocyte colony-stimulating factor (G-CSF) plays an important role in the growth and maturation of granulocytic precursor cells. Although the interaction between G-CSF and its receptor (G-CSF-R) is an obligatory event during proliferation and differentiation of myeloid cells, the signal transduction mechanisms leading to these effects are not completely known. We investigated the kinetics of protein...
Background and purpose: The International Breast Cancer Study Group (IBCSG) has developed an approach for assessing the impact of adjuvant therapy on quality of life (QL) within the framework of international, multilingual clinical trials. The major steps are summarized. Conceptual, methodological and practical issues are discussed with reference to results of two trials closed to accrual (IBCSG VI,...
To document the risk of catheter sepsis associated with central venous catheter changes every 7 days in paediatric burn patients, an analysis of data collected prospectively on 234 such catheters was performed. During an 18-month period there were 301 acutely burned children admitted to a regional paediatric burn facility of whom 53, with an average burn size of 42 per cent TBSA, required 234 central...
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