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Assessment of digestion colonic flora lactulose can be induced to produce hydrogen and prove lactulose with a potential anti-inflammatory effects. We established a mouse model of human ulcerative colitis (UC) by supplying mice with water containing dextran sulfate sodium (DSS). At 7-day, DSS-induced pathogenic outcomes, including loss of body weight, increase of colitis score, pathogenic shortening...
Lactulose, which cannot be digested and absorbed by body, is clinically widely used to treat constipation and hepatic encephalopathy. Fermented by gastrointestinal tract bacteria, lactulose can produce considerable amount of hydrogen, which is protective for DSS-induced colitis as a unique antioxidant. We propose that lactulose is an indirect antioxidant that mobilizes endogenous hydrogen production...
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