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Background and Purposeβ2/3‐subunit‐selective modulation of GABAA receptors by valerenic acid (VA) is determined by the presence of transmembrane residue β2/3N265. Currently, it is not known whether β2/3N265 is part of VA's binding pocket or is involved in the transduction pathway of VA's action. The aim of this study was to clarify the localization of VA's binding pocket on GABAA receptors.
Experimental...
Valerian is a commonly used herbal medicinal product for the treatment of anxiety and insomnia. Here we report the stimulation of chloride currents through GABA A receptors (I GABA ) by valerenic acid (VA), a constituent of Valerian. To analyse the molecular basis of VA action, we expressed GABA A receptors with 13 different subunit compositions in Xenopus oocytes and measured...
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