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The extracellular signal-regulated kinase1/2 (ERK1/2) pathway has a key role in cell survival and brain plasticity, processes that are impaired following exposure to stressful situations. We have recently validated two repeated intermittent stress procedures in male NMRI mice, social threat and repeated exposure to a novel cage, which result in clear behavioral effects following 4 weeks of application...
Acute stress has been shown to affect central serotoninergic system by acting, through increased corticosterone release, on both serotonin (5-HT) turnover and the sensitivity of various receptor subtypes. A new model of stress, the Chronic Ultramild Stress (CUMS), has been recently developed in mice. This stress regimen consisted of various mild stressors separated by at least 2h free periods: cage...
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