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Potassium (K + ) channels are key regulators of vascular smooth muscle cell (VSMC) excitability. In systemic small arteries, K v 7 channel expression/activity has been noted and a role in vascular tone regulation demonstrated. We aimed to demonstrate functional K v 7 channels in human fetoplacental small arteries.Human placental chorionic plate arteries (CPAs) were obtained...
To characterise Chorionic Plate Artery (CPA) function in maternal obesity, and investigate whether leptin exposure reproduces the obese CPA phenotype in normal-BMI women.CPA responses to the thromboxane-A 2 mimetic U46619 (pre/post leptin incubation), to the nitric oxide donor sodium nitroprusside (SNP) and the occurrence of tone oscillations (pre/post leptin incubation) were assessed in 46...
Teenagers are susceptible to delivering small-for-gestational-age infants. Previous studies implicate continued skeletal growth as a contributory factor, and impaired placental development was the primary cause of fetal growth restriction in growing adolescent sheep. The aims of this study were to examine the impact of young maternal age and growth on placental development.Placentas were collected...
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