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Magnetic resonance imaging (MRI) techniques provide non-invasive and non-ionising methods for the highly accurate anatomical depiction of the heart and vessels throughout the cardiac cycle. In addition, the intrinsic sensitivity of MRI to motion offers the unique ability to acquire spatially registered blood flow simultaneously with the morphological data, within a single measurement. In clinical...
The aorta plays a major role in the cardiovascular system and its function and structure are primarily affected by aging, eating habits, life style and other cardiovascular risk factors, inducing increased stiffness which is associated with cardiovascular and cerebral morbi-mortality. Our objective was to develop and validate a robust subject-specific one-dimensional wave propagation numerical model...
Arterial stiffness, which is caused by aging and other cardiovascular risk factors and primarily affects the aorta, is associated with cardiac and cerebral morbidity and mortality. The objective of our study was to non-invasively estimate local biomechanical and hemodynamic biomarkers related to proximal aortic stiffness, by combining cardiovascular magnetic resonance (CMR) data and numerical simulations...
Assessment of diastolic function with phase-contrast (PC) Magnetic Resonance Imaging (MRI) is not used in clinical routine because of the lack of automated analyses. Thus, our aim was to develop a process to automatically analyze PC data. We studied PC data of 25 controls with a custom software, designed for automated segmentation of PC images and analysis of velocity and flow rate curves to derive...
The aim of our study was to develop a 3D model for myocardial wall stress (MWS) evaluation and to test its ability to characterize left ventricular (LV) aging and the effect of aortic valve stenosis (AVS). We studied 65 subjects (45 controls and 20 with AVS) who had a cardiac magnetic resonance (CMR) exam and a measure of central pressures. 3D MWS evaluation combined systolic pressures and an LV geometrical...
The evaluation of diastolic function from phase-contrast (PC) Magnetic Resonance (MR) data in clinical routine is not yet established. Thus, our goal was to develop a reproducible process to analyze PC data. These developments were used to estimate mitral flow and myocardial velocities from PC data of 40 controls. Besides, the reproducibility was assessed on a sub-group of 20 subjects. Transmitral...
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