Search results for: Kirk E. Evoy
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The Journal of Clinical Pharmacology > 61 > S2 > S89 - S99
This article will review the epidemiology and pharmacology of gabapentinoids (gabapentin and pregabalin) relevant to their emerging misuse potential and provide guidance for clinical and regulatory management. Gabapentinoids are γ‐aminobutyric acid analogues that produce their therapeutic effects by inhibiting voltage‐gated calcium channels and decreasing neurotransmitter release. Recently gabapentinoid...
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Background and Aims
Patients with opioid use disorder (OUD) must be able to obtain prescribed buprenorphine/naloxone films (BUP/NX) and naloxone nasal spray (NNS) from a pharmacy promptly to reduce risk for a recurrence of use and subsequent morbidity and mortality. Telephone audits have identified concerning gaps in availability of NNS within US pharmacies, but the availability of BUP/NX has not...
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 38 > 4 > 436 - 443
Objective
Research suggests the medical consequences of gabapentin overuse depend on whether gabapentin is abused alone or with opioids to potentiate an opioid “high.” The objective of this study was to assess predictors of gabapentin overuse with or without concomitant opioids.
Methods
Data were obtained from the Truven Health MarketScan® Commercial Claims and Encounters database for 2013 through...
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Background Ceftaroline fosamil is US Food and Drug Administration-approved for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, but it is not known how ceftaroline is being used in real-world settings or how adverse effects (AEs) and mortality compare to clinical trials. Objective This study describes ceftaroline use, AEs, and mortality in US Veterans...
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Background Gabapentinoid (pregabalin and gabapentin) abuse is increasingly being reported. Objective To assess the extent of gabapentinoid abuse, characteristics of typical abusers, patterns of abuse, and potential harms in order to bring this trend to providers’ attention. Methods A systematic review of MEDLINE, Cochrane Library, ClinicalTrials.gov, and US FDA data, indexed through 28 July 2016,...
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Currents in Pharmacy Teaching and Learning > 2016 > 8 > 3 > 437-441
A number of summer camps across the country have been developed specifically for children with diabetes, most of whom would not be able to attend a traditional summer camp due to the extensive medical attention and scheduling considerations required to continually maintain appropriate glycemic control. These camps rely on the service of various medical practitioners to ensure the safety of the children...
