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Chronic venous hypertension is responsible for protein and fibrinogen escape through the capillary wall into the interstitial space with consequent fibrin polymerization acid formation of perivascular fibrin cuffs. These cuffs may act as a barrier to oxygen diffusion, leading to local ischaemia and tissue necrosis. In order to evaluate urokinase (U.) fibrinolytic activity, a loco-regional infusion...
Sarcoidosis (S), is a multisystem disease where cutaneous lesions takes a foundamental importance because sometimes they represent the only manifestations of S. Lupus Pernio (LP) is a variety of S., localized on face, nose, ears, etc.. In these areas can be observed typical dark-red or red-violet lesions. Respect to the other varieties of S., LP never heals spontaneously. We have treated a young...
Several treatments for Sarcoidosis have been tested to evaluate their ability to modify the abnormal immunologic response which characterises this disease. We have used Melatonin (N-acetyl-5-metoxytriptamine) per os in a long-term treatment (4 months) in 2 patients affected by cutaneous (hemispheric nodular manifestations of 2-3 cm in diameter with reddish-blue color and hard-elastic consistency)...
A 76-year-old woman came to our consultation service for a large painful ulcer (round, reddish-yellow, with a diameter of 6 cm and a depth of 3 cm) of the right leg. The clinical vascular examination and instrumental data (doppler, eco-color-doppler and laser-doppler fluximetry) revealed a normal distribution of cutaneous flow, with no evidence for an obliterative arteriopathy. These data, supported...
An 84 year-old patient came to our observation showing several nodular lesions on the anterior and anterior-medial surface of her left leg. The lesions were of hard elastic consistency, occasionally confluent, with diameter ranging from 0.5 to 4 cm and color varying from ochre-yellow to brownish-red, to slate-brown. These lesions had appeared two years earlier with an eruptive onset. A series of...
The P53 tumor suppressor gene is located on the short arm of chromosome 17. Point mutations in the P53 gene result in an increased stability of the mutant protein. The Bel-2 gene was originally found through chromosomal analysis of the t (14;18) translocation in human follicular limphoma. This bel-2 protein is localized on the mitochondrial inner membrane and suppresses cell apoptosis, a mode of...
Retrograde intravenous pressure infusion (R.I.P.I.) has been recently proposed in the treatment of acute and chronic ischaemic pathologies of the lower legs. This technique has been extended to other inflammatory pathologies. We have treated a 66-year-old woman affected by insulin-dependent diabetes mellitus, who presented an ulcerated phlegmon of the right foot toe. Steam culture revealed that...
P-190 is a chimeric protein localized in the cytoplasm of different cell lines, originating from the translocation of two genes, BCR-ABL. This protein may be considered a tumour specific marker. Its detection is of basic relevance in the early diagnosis of different malignant turnout.The presence of the BCR-ABL chimeric gene is the hallmark of some hematological malignancies i.e acute lymphoblastic...
It is known that the activation of proto-oncogenes and/or the inactivation of tumor suppressor genes result in enhanced rates of cellular proliferations. The concept of physiologic cell death, (apoptosis) and its relevance to the maintenance of cell populations has been recognized for several years. The protein encoded by the bcl-2 gene is a critical regulator of programmed cell death. Recent studies...